Human Inheritance Lab

How the analyzer works: for each mode it searches every possible set of genotypes for the people shown and asks whether Mendelian transmission can produce exactly these affected and unaffected people. "Ruled out" means no genotypes work, and the contradicting people are listed. Relative fit compares the modes that do work, assuming the variant is rare (allele frequency 1%), each mode equally likely beforehand, 80% penetrance when that option is on and a new mutation rate of 1 in 10,000 per transmission when that option is on. Mitochondrial inheritance is treated as homoplasmic. Partners who married in are assumed unrelated.

Problems are randomly generated fictional families. Unless a problem says otherwise, conditions are rare, fully penetrant, with no new mutations, and partners from outside the family are not carriers. Type probabilities as a fraction (1/9), a decimal (0.111), a percent (11.1%) or "1 in 9". Answers within about 2% of the exact value are accepted (a little more for Hardy-Weinberg approximations such as 2pq ≈ 2q).