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Microbiology · Chapter 13

Primary vs Secondary Response

The first time the body meets an antigen it answers slowly and weakly. The next time it remembers, and the answer is faster and far bigger. Pick a schedule, then drag the day slider and watch the IgM and IgG curves move. Watch where the total crosses the protective line.

Antibody over one yearlog scale

Antibody titer over time for the chosen dosing schedule
IgGIgMprotective line
Day
0
Total titer
0
Dominant class
none
Protected
no

Primary against secondaryfrom your own schedule

Reading the two curves. IgM is the first class a plasma cell makes, so the gold line leads on a first exposure. It also fades fastest, because its plasma cells are short-lived. IgG comes later through class switching, climbs higher, and lasts far longer. On a second exposure the gold line barely moves while the purple line jumps, and that is the signature of memory.
Why a titer can look low and still mean protection. A measured antibody level only counts the antibody floating in blood right now. Memory cells are not counted at all. Someone can sit under the green line and still clear the microbe in days, because the memory cells restart the factory on contact.
Day 0nothing in the blood yet
Pick a schedule
0