📖 ContentsChapter 1 · Case History
Part III Clinical Competency · Chapter 1 · Case History

The Case History

On Part III, the history is where the case is won or lost: the vignette hands you a few words from the patient, and the item asks what you should ask next, what the answer means and which diagnosis it makes likely. In the clinic the same skill decides whether a patient with back pain gets an adjustment, an x-ray or a same day trip to the emergency department. This chapter teaches you to turn a vague complaint into a focused, defensible history that has already narrowed the differential before you lay a hand on the patient.

By the end of this chapter you can

  • Organize the history of present illness with OPQRST and OLDCARTS and explain what each answer suggests about the tissue at fault.
  • Use the mechanism of injury and the timeline to predict the injured structure and the likelihood of fracture.
  • Explain how past medical, surgical, medication, family and social history raise or lower the probability of specific diagnoses.
  • Run a systematic review of systems and ask the exact questions that uncover cancer, infection, fracture, cauda equina syndrome, vascular and visceral causes of spinal pain.
  • Recognize yellow flags that predict chronic disability and name the screening tools that measure them.
  • Separate mechanical, nonmechanical, inflammatory, radicular and visceral pain patterns from the history alone.
  • Apply pretest probability and pattern recognition to build a ranked differential with a must not miss alternative.
  • Adapt history taking for pediatric, geriatric, pregnant and non-English speaking patients, including proper use of interpreters.
  • Document the history in a clear, defensible record that supports the diagnosis, the plan and informed consent.

Section 1The chief complaint and history of present illness

What the history is for

Studies in primary care have shown for decades that the history alone leads to the correct diagnosis in roughly 70 to 80 percent of patients; the physical examination and tests add comparatively little once a good history is in hand. For a chiropractor the history has three jobs. First, it sorts the patient into one of three diagnostic bins: serious pathology (about 1 to 2 percent of spinal pain patients), radicular syndrome (about 5 to 10 percent) and nonspecific mechanical pain (about 90 percent). Second, it generates a short list of hypotheses that the examination will test. Third, it establishes the baseline against which you will judge progress and on which your record stands if the case is ever reviewed.

The standard order is: identifying data, chief complaint (CC), history of present illness (HPI), past medical history (PMH), medications and allergies, family history (FH), personal and social history (SH), and the review of systems (ROS). Part III items test the logic inside each part: which question best discriminates between two diagnoses, which answer is a red flag, and which piece of history is missing.

The chief complaint

The chief complaint is recorded in the patient's own words, with its duration: "Low back pain going down my left leg for three weeks." It should not be a diagnosis ("sciatica" or "subluxation") because a premature label closes the mind. If a patient has several complaints, list them, ask which matters most, and take a separate HPI for each one, because a new symptom (for example, a headache in a patient who came for neck pain) may have a completely different cause.

OPQRST and OLDCARTS

Both mnemonics cover the same ground. OPQRST is Onset, Provocation and Palliation, Quality, Region and Radiation, Severity, and Timing. OLDCARTS is Onset, Location, Duration, Character, Aggravating factors, Relieving factors, Timing and Severity. What matters on the board is not the acronym but what each answer means.

ElementKey questionAnswerWhat it suggests
OnsetHow did it start?Sudden with a specific load (lift and twist)Mechanical injury: disc, facet, muscle strain
OnsetHow did it start?Insidious, no event, steadily worseningDegenerative, inflammatory, neoplastic or infectious; ask red flag questions
OnsetHow did it start?Sudden, severe, "worst ever", no traumaVascular (dissection, aneurysm, hemorrhage) until proven otherwise
ProvocationWhat makes it worse?Sitting, bending, cough, sneeze, strainDiscogenic or radicular (raised intradiscal or intrathecal pressure)
ProvocationWhat makes it worse?Standing, extension, walking downhillFacet joint or central or lateral stenosis
PalliationWhat makes it better?Lying down, rest, position changeMechanical pain
PalliationWhat makes it better?Nothing; or exercise helps and rest does notNonmechanical (tumor, infection, visceral); exercise relief suggests inflammatory spondyloarthritis
QualityWhat does it feel like?Deep acheSomatic (joint, ligament, muscle, annulus)
QualityWhat does it feel like?Burning, electric, shooting, pins and needlesNeuropathic or radicular
QualityWhat does it feel like?Tearing or rippingArterial dissection
Region and radiationWhere does it go?Narrow band below the knee to the footRadicular pain (nerve root)
Region and radiationWhere does it go?Diffuse, buttock and thigh, stops above the kneeSomatic referred pain (facet, SI joint, disc)
Severity0 to 10, and what can you not do?Rating plus functional lossBaseline for outcome measures (NPRS, Oswestry, NDI)
TimingWhen is it worst?Morning stiffness over 30 to 60 minutesInflammatory arthritis
TimingWhen is it worst?Night pain, unrelieved by positionRed flag: tumor or infection
TimingWhen is it worst?End of day, after activityMechanical or degenerative (osteoarthritis)

Mechanism of injury

The mechanism is the history's best predictor of which tissue failed and whether a fracture is possible. Ask exactly what happened, the forces and their direction, the position of the body, what the patient felt and heard, and what they could do immediately afterward.

Chief complaint "My back hurts" (patient's words) Onset and mechanism Event or insidious? Load, direction, force Fracture possible? Behavior of pain Changes with load? Rest versus exercise Night and morning Distribution Local or referred? Above or below knee Dermatomal band? Mechanical Varies with load Eased by rest Ache, above knee Conservative care Radicular Leg worse than back Below knee, burning Cough, sneeze worse Track neuro status Inflammatory Age under 40 AM stiffness long Better with exercise Labs, co-manage Nonmechanical Constant, at night Nothing eases it Systemic symptoms Workup or refer
Figure 1.1 How the history of present illness narrows a vague complaint. Three groups of questions (onset and mechanism, behavior of the pain, and its distribution) sort most patients into one of four patterns before the examination begins.

The timeline

Duration classifies spinal pain as acute (under 6 weeks), subacute (6 to 12 weeks) and chronic (over 12 weeks, or 3 months). The trajectory matters as much as the duration. Most acute mechanical episodes improve substantially within 2 to 6 weeks; a course that is steadily progressive despite rest and appropriate care is a red flag in itself. Ask about previous episodes, because a recurrent pattern of short mechanical episodes with full recovery between them is reassuring, while a first episode at age 55 or later deserves more caution. Ask what treatment has been tried and with what result: failure to improve after about four weeks of appropriate conservative care is a common trigger for imaging or referral.

Aggravating and relieving factors in more depth

The behavior of pain under load is one of the strongest clues to the pain generator. Flexion intolerance (worse with sitting, bending, lifting, driving, getting out of a chair, morning) fits a discogenic source, because flexion loads the anterior column and pushes nuclear material posteriorly. Extension intolerance (worse with standing, walking, lying prone, reaching overhead) fits the facet joints or stenosis, because extension loads the posterior elements and narrows the canal and foramina. Pain that is worse with cough, sneeze or straining (Valsalva) suggests a space occupying lesion that raises intrathecal pressure on a sensitized root, usually a disc herniation but occasionally a tumor. Pain relieved by sitting or flexing forward and brought on by walking, with leg symptoms, is the hallmark of neurogenic claudication from lumbar spinal stenosis, while leg pain on walking that eases with simply standing still suggests vascular claudication.

Worked examples: turning a vague complaint into a focused history

Case. A 38 year old warehouse worker says, "My back went out." Your first questions establish onset: he was lifting a 25 kg box from the floor and twisting to the left when he felt a sharp pain in the right low back. Over two days he developed burning pain down the back of the right thigh and calf to the outer foot and little toe. Sitting and driving are worst; lying on his side with knees bent helps; a cough makes his leg shoot. He has no bowel or bladder change and no saddle numbness.
Reasoning: Flexion plus rotation under load, leg pain worse than back pain, pain below the knee in an S1 distribution and cough aggravation make a right L5 to S1 posterolateral disc herniation with S1 radicular pain the leading hypothesis. Your examination is now focused: straight leg raise, slump, S1 myotome (plantarflexion, toe walking), Achilles reflex and lateral foot sensation. The negative cauda equina questions must be documented. Do not stop at "sciatica"; record the dermatome and the absence of red flags.
Case. A 67 year old retired teacher reports "aching legs" for a year. Clarifying questions reveal bilateral buttock and thigh heaviness and tingling that start after walking about two blocks, worse walking downhill, relieved within a few minutes by sitting or leaning on a shopping cart, but not by standing still. Cycling is comfortable.
Reasoning: Relief by flexion (sitting, leaning forward, the "shopping cart sign"), not by simply stopping, and tolerance of cycling point to neurogenic claudication from lumbar spinal stenosis rather than vascular claudication. The must not miss alternative is peripheral arterial disease, so palpate pedal pulses and consider an ankle brachial index. Asking only "Does walking hurt?" would not have separated the two.
Board tip. When an item asks for the "most appropriate next question," choose the question whose answer would change your management. In a back pain case with leg symptoms, that is usually a cauda equina screen (bladder, bowel, saddle sensation) or a question that separates neurogenic from vascular claudication (does standing still relieve it, or must you sit and bend forward?).
Key point

The history of present illness turns a vague complaint into a testable hypothesis. Onset and mechanism predict the injured tissue and the risk of fracture; behavior under load separates mechanical from nonmechanical and flexion from extension intolerance; distribution separates somatic referred from radicular pain. A focused history makes the examination short and pointed.

Section 2Past, family, personal and social history

Why the background history matters

The background history changes pretest probability. The same complaint of thoracic pain means one thing in a fit 25 year old rower and something very different in a 70 year old woman on long term prednisone or a 60 year old man treated for prostate cancer five years ago. Each element below should be asked with a purpose: to raise or lower the probability of a specific diagnosis, or to identify a contraindication to a specific treatment.

Past medical and surgical history

Medications and allergies

Medications both reveal hidden diagnoses and change what you can safely do. Ask about prescription drugs, over the counter drugs, supplements and recreational drugs, and record allergies with the type of reaction.

MedicationWhy it matters in the caseAction
Anticoagulants (warfarin, apixaban, rivaroxaban, dabigatran) and antiplateletsBleeding risk: epidural or soft tissue hematoma, bruising with deep soft tissue workModify force; avoid high velocity thrust if anticoagulation is unstable; document INR if on warfarin
Long term corticosteroidsOsteoporosis, compression fracture, avascular necrosis of the femoral head, infection risk, masked feverLower threshold for imaging after minor trauma; gentle, low force techniques
Fluoroquinolones (ciprofloxacin, levofloxacin)Tendinopathy and Achilles rupture, especially with steroids and age over 60Ask in any new tendon pain; avoid aggressive loading
StatinsMyalgia; rarely myopathy or rhabdomyolysis (dark urine, weakness)Diffuse muscle pain after starting a statin: refer to prescriber, CK testing
NSAIDsGI bleeding, renal impairment, hypertension; may mask inflammatory symptomsAsk about black stools and epigastric pain
OpioidsConstipation, sedation, dependence; long term use predicts chronicityNote dose and duration; yellow flag
Bisphosphonates, denosumabIndicate known osteoporosis; rare atypical femoral fracture (thigh pain)Modify thrust; image new thigh or groin pain
Oral contraceptives, estrogenVenous thromboembolism risk; slight stroke riskConsider DVT in calf pain and swelling
Antihypertensives, diureticsOrthostatic hypotension, dizziness, cramps (electrolytes)Rise slowly from the table; consider in dizziness
Antidepressants, anticonvulsants (gabapentin)Indicate depression or neuropathic pain; dizzinessYellow flag context; fall risk in older adults
Isotretinoin, aromatase inhibitorsArthralgia and myalgia as side effectsConsider drug cause of diffuse pain

Family history

Family history raises the probability of conditions with a genetic component. A first degree relative with ankylosing spondylitis or other spondyloarthritis, psoriasis or inflammatory bowel disease supports inflammatory back pain (HLA-B27). A family history of abdominal aortic aneurysm raises AAA risk several fold. Family history of premature cardiovascular disease (a male relative under 55 or a female relative under 65) matters in chest, jaw and arm pain. Ask also about cancer (breast, colon, prostate), osteoporosis and hip fracture in a parent (a FRAX risk factor), scoliosis (adolescent idiopathic scoliosis clusters in families), gout, rheumatoid arthritis, diabetes, migraine, connective tissue disorders and sudden cardiac death in a young relative (relevant to athletes).

Personal and social history

ElementAsk aboutHow it changes the working diagnosis
OccupationPosture, lifting, vibration, repetitive tasks, job satisfaction, time off workHeavy lifting and whole body vibration (drivers) predict disc disease; keyboard work fits upper crossed syndrome and carpal tunnel; job dissatisfaction is a yellow flag
Physical activity and sportType, volume, recent changeRecent training increase suggests stress fracture or tendinopathy; hyperextension sports suggest spondylolysis
TobaccoPack years, current useLung cancer (Pancoast tumor with shoulder and C8 to T1 pain), disc degeneration, poor bone and wound healing, PAD, AAA
AlcoholQuantity; CAGE or AUDIT C screeningPancreatitis (epigastric pain to the back), avascular necrosis, falls, neuropathy, osteoporosis
Recreational drugsInjection drug useSpinal epidural abscess, vertebral osteomyelitis, endocarditis
SleepHours, waking from pain, positionWaking from pain that no position eases is a red flag; poor sleep amplifies pain and predicts chronicity
Stress and moodLife events, depression and anxiety screening (PHQ-2)Psychological distress predicts chronic disability; muscle tension headache
Diet and weightRecent weight change, calcium and vitamin D, eating disordersUnexplained weight loss is a red flag; low energy availability in athletes causes stress fractures
Sexual and travel historyNew partners, recent travelReactive arthritis after chlamydia or enteric infection; disseminated gonococcal arthritis; tuberculosis exposure
Home and supportWho is at home, stairs, fallsFall risk and fracture in the elderly; ability to follow a home program
Litigation and compensationOpen claims, lawyer involvedA yellow flag for slower recovery, not proof of exaggeration
Same complaint, different background: history shifts pretest probability Low concern Watchful, targeted tests Image, labs or refer Baseline Adult with back pain Cancer about 1 percent Age over 50 or weight loss, or failed 4 weeks of care Each modest alone Drug history Steroids: fracture IV drug use: infection risk Prior cancer Positive LR about 15 Probability jumps to roughly 10 percent Red flags combine: two or more weak flags together carry far more weight than one
Figure 1.2 Background history moves the patient along the probability scale. A single weak flag, such as age over 50, changes little; a history of cancer moves the patient decisively toward imaging or referral, and several weak flags together do the same.

How each piece changes the working diagnosis

Think of each answer as a weight on a scale. Age over 50, prior cancer, unexplained weight loss and failure of a month of care push toward malignancy. Fever, injection drug use, recent infection (urinary tract, skin), immunosuppression, diabetes and recent spinal procedures push toward infection. Older age, osteoporosis, steroids and trauma push toward fracture. Age under 40, morning stiffness, alternating buttock pain, uveitis, psoriasis, inflammatory bowel disease and a family history of spondyloarthritis push toward axial spondyloarthritis. Smoking, hypertension, male sex, age over 60 and family history push toward AAA. A young, active, healthy patient with a clear mechanical onset sits firmly at the benign end.

Case. A 71 year old woman reports sudden sharp midthoracic pain that began when she sneezed two days ago. The pain wraps around the chest and is worse rising from bed. She takes prednisone 10 mg daily for polymyalgia rheumatica and had a wrist fracture after a fall at 64.
Reasoning: Minimal trauma, older age, long term corticosteroids and a prior fragility fracture make an osteoporotic vertebral compression fracture by far the most likely diagnosis. The next step is radiographs of the thoracic spine before any manual therapy. High velocity thrust to the thoracic spine is contraindicated until fracture is excluded and bone quality is known. Ask also about weight loss and cancer, because a pathologic fracture from myeloma or metastasis is the must not miss alternative.
Case. A 32 year old man has had low back and alternating buttock pain for eight months. He is stiff for more than an hour each morning, wakes in the second half of the night with pain, feels better after his gym session and worse after a lazy weekend. Last year he was treated for a painful red eye. His father "had a stiff back his whole life."
Reasoning: Onset before 40, insidious onset, improvement with exercise but not rest, night pain improving on getting up, alternating buttock pain, prior anterior uveitis and a suggestive family history make axial spondyloarthritis (ankylosing spondylitis) the leading diagnosis. Order or request HLA-B27, CRP and imaging of the sacroiliac joints, and arrange rheumatology co-management. Treating as simple mechanical back pain would delay disease modifying therapy.
Board tip. Two history facts carry the most weight for spinal malignancy: a prior history of cancer and failure to improve after about a month of appropriate care, especially when combined with age over 50 and unexplained weight loss. For spinal infection the key facts are fever, injection drug use, immunosuppression and a recent infection or spinal procedure.
Key point

The past, family, personal and social history set the pretest probability of each diagnosis and expose contraindications. Cancer history, steroid use, anticoagulation, injection drug use, smoking and a family history of spondyloarthritis or aneurysm should each reshape the differential and the treatment plan.

Section 3Review of systems and red flag questioning

The systematic review of systems

The review of systems (ROS) is a structured head to toe inventory of symptoms the patient may not connect with the chief complaint. Its purpose in a chiropractic case is to find the patient whose musculoskeletal complaint is really systemic or visceral disease, and the patient who has a second problem that needs attention. A written intake questionnaire covers the ground efficiently; the clinician then asks follow up questions about every positive answer and about the systems most relevant to the complaint.

SystemKey questionsA positive answer may point to
ConstitutionalFever, chills, night sweats, fatigue, unexplained weight loss (more than about 5 percent in 6 to 12 months)Cancer, infection, inflammatory disease, endocrine disease
SkinRash, psoriasis, new or changing moles, bruisingPsoriatic arthritis, melanoma, Lyme disease, bleeding disorder, shingles
Head, eyes, ears, nose, throatHeadache pattern, visual loss or double vision, red painful eye, hearing loss, tinnitus, vertigoGiant cell arteritis, uveitis (spondyloarthritis), vertebrobasilar insufficiency, acoustic neuroma
CardiovascularChest pain on exertion, palpitations, leg swelling, calf pain on walkingAngina, arrhythmia, heart failure, DVT, peripheral arterial disease
RespiratoryCough, hemoptysis, dyspnea, pleuritic painLung cancer, pneumonia, pulmonary embolism, pleurisy, tuberculosis
GastrointestinalDysphagia, heartburn, nausea, change in bowel habit, black or bloody stools, pain related to mealsPeptic ulcer, pancreatitis, cholecystitis, colorectal cancer, inflammatory bowel disease
GenitourinaryDysuria, frequency, hematuria, flank pain, retention, discharge, menstrual relationshipPyelonephritis, kidney stone, prostate disease, cauda equina, endometriosis, ectopic pregnancy
MusculoskeletalOther joints, morning stiffness, swellingInflammatory arthritis, polymyalgia rheumatica, gout
NeurologicWeakness, numbness, gait change, clumsy hands, falls, seizures, speech or swallowing changeMyelopathy, stroke, multiple sclerosis, peripheral neuropathy
PsychiatricLow mood, loss of interest, anxiety, sleep disturbance, suicidal thoughtsDepression, anxiety; yellow flags
EndocrineHeat or cold intolerance, polyuria, polydipsiaThyroid disease, diabetes
Hematologic and lymphaticEasy bruising, enlarged nodes, recurrent infectionsLeukemia, lymphoma, myeloma

Red flag questions by category

Red flags are features of the history and examination that raise the probability of serious pathology. Individually most are weak; their value lies in combinations and in the strong ones. Know the question to ask for each threat and the urgency of referral if it is positive.

ThreatHistory red flagsUrgency if suspected
MalignancyPrior cancer; age over 50; unexplained weight loss; failure to improve after 4 to 6 weeks; constant, progressive pain; night pain unrelieved by position; thoracic painUrgent (days) workup; same day if new neurological deficit (metastatic cord compression)
Infection (osteomyelitis, discitis, epidural abscess)Fever or chills; injection drug use; immunosuppression; diabetes; recent UTI, skin infection or spinal procedure; constant painSame day medical evaluation; emergency if neurological signs
FractureSignificant trauma (or minor trauma in the elderly); osteoporosis; long term steroids; age over 70Image before manual therapy; emergency if unstable or neurological deficit
Cauda equina syndromeUrinary retention or new incontinence; saddle (perineal) numbness; fecal incontinence; bilateral or progressive leg weakness or sciatica; sexual dysfunctionEmergency: same day emergency department for MRI and surgical decompression
Abdominal aortic aneurysmAge over 60, male, smoker, hypertension; deep, boring or tearing back or abdominal pain unrelated to movement; pulsatile abdominal massEmergency if symptomatic or unstable; known small aneurysm needs vascular follow up
Cervical artery dissectionSudden severe unusual neck pain or headache, often after minor trauma; dizziness, diplopia, dysarthria, dysphagia, drop attacks, ataxia, nausea, nystagmus, numbness (the 5 Ds and 3 Ns); Horner syndromeEmergency: stroke pathway
MyelopathyClumsy hands, dropping things, unsteady gait, bilateral paresthesias, bladder changeUrgent referral; emergency if rapidly progressive
Visceral diseasePain unchanged by movement; related to eating, urination or menstruation; associated systemic or organ symptomsDepends on organ: same day for suspected ectopic pregnancy, MI, pancreatitis, pyelonephritis
Inflammatory arthritisAge under 40, morning stiffness over 30 minutes, better with exercise, uveitis, psoriasis, IBDRoutine to soon rheumatology co-management
Giant cell arteritisAge over 50, new headache, scalp tenderness, jaw claudication, visual disturbance, polymyalgia symptomsSame day: risk of permanent blindness

Cauda equina syndrome: the questions you must ask

Cauda equina syndrome results from compression of multiple lumbosacral roots below the conus medullaris, most often by a large central disc herniation at L4 to L5 or L5 to S1, less often by tumor, abscess, hematoma or severe stenosis. The single most sensitive finding is urinary retention (sensitivity about 90 percent); with retention, overflow incontinence follows. Ask every patient with back pain and leg symptoms, in plain words: "Have you had any trouble starting or stopping your urine, or any leaking?" "Any numbness between your legs or around your back passage, for example when you wipe after the toilet?" "Any change in bowel control?" "Any new problem with sexual function?" "Is the leg pain on both sides, or getting worse?" Document both positive and negative answers. Incomplete cauda equina syndrome (altered urinary sensation, reduced saddle sensation, retained control) carries a much better outcome after decompression than the retention stage, which is why the question must be asked early and the patient told to return immediately if any of these symptoms appear.

Spinal pain Ask the screen every time Cancer Prior cancer Age over 50, weight loss Night pain, no relief No better in 4 weeks Infection Fever, chills, sweats Injection drug use Immunosuppression Recent UTI or procedure Fracture Major trauma Minor trauma if elderly Osteoporosis Long term steroids Cauda equina Urinary retention Saddle numbness Bowel or sexual change Bilateral leg symptoms Vascular, visceral Tearing pain (AAA, dissection), 5 Ds 3 Ns Pain with meals, urine Not changed by motion Color shows urgency Urgent workup Often emergency
Figure 1.3 The red flag screen. Five threats, each with its own short list of history questions; cauda equina syndrome and symptomatic vascular causes are usually emergencies, while suspected cancer, infection and fracture need prompt workup and immediate referral if neurological signs appear.

Vascular and visceral causes from the history

Visceral pain refers to the spine through shared segmental innervation, and its giveaway is that it does not behave mechanically: posture, movement and palpation do not reproduce it, while eating, urination, menstruation or exertion do. Kidney stones cause colicky flank pain radiating to the groin, with restlessness (the patient cannot get comfortable, in contrast to the stillness of mechanical pain) and hematuria. Pyelonephritis adds fever and dysuria. Pancreatitis gives boring epigastric pain through to the back, eased by leaning forward, often after alcohol or a fatty meal. Peptic ulcer on the posterior duodenal wall gives midthoracic pain related to meals. Gallbladder disease refers to the right scapula after fatty meals. Myocardial ischemia refers to the left arm, jaw, neck and interscapular region with exertion, sweating and dyspnea. Aortic dissection causes sudden tearing chest or interscapular pain. Gynecologic disease (endometriosis, ovarian cyst, ectopic pregnancy) causes low back and pelvic pain related to the menstrual cycle; in any woman of reproductive age with low abdominal or back pain, ask the date of the last menstrual period.

Cervical red flags and the vertebrobasilar screen

Before treating the neck, ask about the features of cervical artery dissection and vertebrobasilar insufficiency: recent onset of severe, unusual neck pain or occipital headache (often described as different from any previous headache), especially after minor trauma, sport or prolonged neck extension; and the brainstem symptoms summarized as the 5 Ds and 3 Ns: dizziness, diplopia, dysarthria, dysphagia, drop attacks, ataxia of gait, nausea, nystagmus and numbness (often facial or perioral). Internal carotid dissection may produce an ipsilateral Horner syndrome (ptosis, miosis, anhidrosis) and pulsatile tinnitus. A thunderclap headache (maximal within a minute) suggests subarachnoid hemorrhage. Also ask about features of upper cervical instability: rheumatoid arthritis, Down syndrome, recent trauma, a sense that the head is heavy or unstable, and bilateral paresthesias.

Case. A 44 year old woman presents with left sided neck pain and a left occipital headache that began suddenly four days ago while she was reversing her car and turned her head sharply. She calls the headache "nothing like my usual headaches." Since yesterday she has felt unsteady and had two episodes of double vision.
Reasoning: New, severe, unusual neck pain and headache after minor rotation, followed by brainstem symptoms (diplopia, ataxia), is the classic picture of vertebral artery dissection. This is an emergency: do not examine with provocative positional tests and do not treat the neck; arrange immediate transfer to the emergency department for vascular imaging (CT angiography or MR angiography). Document the time and the advice given.

Yellow flags: predicting chronicity

Yellow flags are psychosocial factors that predict persistent pain and disability rather than serious disease. They include fear avoidance beliefs (the belief that movement or work will cause harm), catastrophizing, low mood and depression, anxiety, passive coping (waiting to be fixed), poor sleep, social withdrawal, job dissatisfaction and conflict at work, compensation and litigation issues, and a history of long time off work. Related color flags include blue flags (the worker's perception of the workplace) and black flags (system or contextual barriers such as employer policy or the compensation system). Orange flags denote psychiatric disorders such as major depression or personality disorder that require referral.

ToolWhat it measuresHow it is used
STarT Back Screening ToolNine items stratifying low, medium or high risk of poor outcome in low back painMatches treatment intensity to risk; high risk patients need psychologically informed care
Fear Avoidance Beliefs Questionnaire (FABQ)Fear avoidance for physical activity and workHigh work subscale predicts delayed return to work
Pain Catastrophizing ScaleRumination, magnification, helplessnessIdentifies catastrophizing as a treatment target
Orebro Musculoskeletal Pain QuestionnaireBroad psychosocial risk of long term disabilityScreening in workers with spinal pain
PHQ-2 and PHQ-9DepressionTwo question screen; refer positive and any suicidal ideation
Oswestry Disability Index, Neck Disability IndexFunction in low back or neck painOutcome tracking; a 10 point change is a common clinically important difference on the Oswestry
Board tip. Red flags predict serious disease and call for workup or referral. Yellow flags predict chronic disability and call for education, reassurance, graded activity and, when severe, psychologically informed care or referral. An item that describes fear of movement and a pending claim is testing yellow flags, not malingering.
Key point

The review of systems finds the systemic and visceral disease that hides behind musculoskeletal complaints. Ask the red flag questions for cancer, infection, fracture, cauda equina syndrome, vascular and visceral disease in every spinal patient and document the answers; screen yellow flags in everyone, because they predict who will become chronic.

Section 4Building differential diagnoses from the history

From pattern recognition to probability

Experienced clinicians reason in two modes. Pattern recognition (fast, intuitive) matches the story to an illness script stored from experience: "young man, lift and twist, leg pain below the knee worse with sitting: disc." Analytical reasoning (slow, deliberate) lists possibilities systematically and weighs evidence for each. Pattern recognition is efficient but vulnerable to cognitive biases; analytic reasoning is the check on it. Good practice is to form an early hypothesis from the pattern and then deliberately ask, "What else could this be, and what must I not miss?"

Pretest probability is the probability of a diagnosis before a test is performed, and it comes chiefly from prevalence in the setting and from the history. A test result moves probability, and the size of that move is captured by the likelihood ratio (LR). A positive LR above 10 or a negative LR below 0.1 produces a large, often decisive shift; LRs of 2 to 5 (or 0.2 to 0.5) produce small but sometimes important shifts; an LR near 1 changes nothing. Every history question is a test in this sense. A history of cancer in a back pain patient carries a positive LR near 15; age over 50 alone carries a positive LR near 2.7; "pain not relieved by bed rest" has an LR barely above 1. A highly sensitive finding, when absent, helps rule a condition out (SnNout); a highly specific finding, when present, helps rule it in (SpPin).

Every history answer is a test that moves probability 0% 100% Test threshold below: stop, reassure Treatment threshold above: act, refer, treat Pretest probability Positive finding, LR+ above 10 Negative finding, LR minus below 0.1 Between the thresholds: gather more history, examine, or test
Figure 1.4 Probability thinking. History begins at the pretest probability; a strong positive finding pushes the diagnosis past the treatment threshold, a strong negative finding pulls it below the testing threshold, and the uncertain middle zone is where more questions, examination and tests earn their keep.

Mechanical versus nonmechanical pain

The first branch point in any spinal differential is whether the pain is mechanical. Mechanical pain changes with posture, movement and load, has a position of relief, can be reproduced on examination, and usually follows a recognizable onset. Morning stiffness is brief (under 30 minutes). Nonmechanical pain is constant or progressive, does not change with position, is often worse at night, and is accompanied by systemic or organ specific symptoms. Nonmechanical pain has three broad sources: systemic disease (tumor, infection, inflammatory arthritis, metabolic bone disease), visceral referral and neuropathic or central pain. A mixed picture is common, for example a mechanical overlay on a metastatic lesion, so a mechanical component never excludes serious disease when red flags are present.

PresentationKey clue in the historyMost likely diagnosisMust not miss alternative
Acute low back pain after lifting, no leg painClear mechanical onset, eased by restNonspecific mechanical low back pain (strain, facet, annular)Compression fracture in older or steroid treated patient
Back and leg pain below knee, worse sitting and coughingDermatomal radiation, leg worse than backLumbar disc herniation with radiculopathyCauda equina syndrome; tumor if constant and progressive
Older adult, leg pain on walking, eased by sitting and bendingFlexion relief, shopping cart signLumbar spinal stenosis (neurogenic claudication)Peripheral arterial disease
Young adult, morning stiffness, better with exerciseInflammatory profile, uveitis or psoriasisAxial spondyloarthritisInfection (discitis) if fever
Adolescent athlete, extension painRepetitive hyperextension sportSpondylolysisOsteoid osteoma (night pain relieved by aspirin or NSAIDs)
Older smoker, deep constant back and abdominal painNot changed by movement, vascular riskAbdominal aortic aneurysmPancreatic cancer, retroperitoneal disease
Thoracic pain with night pain and weight lossNonmechanical, constitutional symptomsMetastatic disease or myelomaInfection; aortic disease
Fever, constant back pain, injection drug useInfectious risk factorsVertebral osteomyelitis or epidural abscessEndocarditis with septic emboli
Flank pain to groin, restless, hematuriaColicky, cannot get comfortableUreteral calculusAAA (can mimic renal colic in older men)
Neck pain, clumsy hands, unsteady gaitBilateral, upper motor neuron symptomsCervical spondylotic myelopathyMultiple sclerosis, cord tumor
Arm pain into thumb, worse with neck extensionDermatomal, positionalC6 radiculopathyPancoast tumor (smoker, C8 to T1, Horner)
Widespread pain, fatigue, poor sleep, tender pointsDiffuse, nonanatomical, chronicFibromyalgiaHypothyroidism, polymyalgia rheumatica, inflammatory arthritis

Radicular, referred and central patterns

Separating the distribution of pain is the second branch point. Somatic referred pain arises from a spinal structure (facet joint, disc, sacroiliac joint, muscle) and is felt as a deep, diffuse, poorly localized ache in the same segmental territory, usually not below the knee in the lower limb or below the elbow in the upper. Radicular pain arises from an irritated nerve root and is sharp, shooting or burning, felt in a narrow band, often extends below the knee into the foot, and is usually worse in the limb than in the back. Radiculopathy is the objective loss of root function (dermatomal sensory loss, myotomal weakness, reduced reflex). Myelopathy is cord compression with bilateral symptoms, clumsy hands, gait disturbance and upper motor neuron signs. Visceral referred pain follows the dermatomes of the organ's sympathetic afferents (heart to T1 to T4 and the left arm; gallbladder to the right scapula; kidney to the flank and groin; pancreas to the upper lumbar region). Nociplastic pain (central sensitization) is widespread, disproportionate, with allodynia and hyperalgesia.

Avoiding cognitive traps

Case. A 63 year old man who smokes 30 cigarettes a day has had low back pain for six weeks. He insists he "strained it gardening." The pain is constant, deep and boring, unchanged by sitting, standing or lying, and worse at night. He has lost 6 kg without dieting. Treatment with heat and over the counter analgesics has not helped.
Reasoning: The patient's anchor is gardening, but the history is nonmechanical: constant pain unchanged by position, night pain, weight loss, age over 50 and heavy smoking. The leading considerations are metastatic disease (lung, prostate), multiple myeloma and an abdominal aortic aneurysm, with pancreatic cancer also possible. Before examining, the history already demands abdominal palpation for a pulsatile mass, a neurological screen, radiographs, and laboratory tests (CBC, ESR or CRP, calcium, alkaline phosphatase, PSA, serum protein electrophoresis) or prompt medical referral. Manipulation is deferred until serious disease is excluded.
Case. A 29 year old woman has had right low back and flank pain for one day. It comes in waves, radiates to the right groin, and she cannot keep still on the table. She has vomited twice and noticed pink urine. Movements of the spine do not change the pain.
Reasoning: Colicky pain radiating from flank to groin, restlessness, nausea and hematuria, unaffected by spinal movement, point to a right ureteral calculus. Ask about fever and dysuria (an infected obstructed kidney is an emergency) and the last menstrual period (ectopic pregnancy is the must not miss alternative in a woman of reproductive age). Refer the same day for urinalysis, pregnancy test and imaging; this is not a chiropractic lesion.
Board tip. Items that end with "Which of the following is the most likely diagnosis?" usually hinge on one discriminating clue in the history: relief by flexion (stenosis), relief by exercise (spondyloarthritis), restlessness (renal colic), meal relationship (ulcer, gallbladder), tearing quality (dissection), or saddle numbness (cauda equina). Find that clue first, then check it against the age and risk factors.
Key point

A good history yields a ranked differential before the examination begins: a leading diagnosis from pattern recognition, a must not miss alternative from red flags, and the specific examination findings that will separate them. Mechanical versus nonmechanical behavior and radicular versus referred distribution are the two most useful branch points, and pretest probability decides how hard to look.

Section 5Communication, special populations and documentation of the history

Asking questions well

Begin with open ended questions ("Tell me about the pain," "What brings you in today?") and allow the patient to speak without interruption for the first minute or two; most patients finish their opening statement in under two minutes, and interrupting early loses information. Then narrow with focused questions ("Where exactly does it go?") and finish with closed questions that confirm or exclude specific features ("Any numbness between your legs?"). Avoid leading questions ("The pain doesn't go down your leg, does it?") and compound questions that ask two things at once. Use facilitation (nodding, "go on"), clarification ("What do you mean by dizzy: is the room spinning, or do you feel faint?"), reflection and summarizing ("Let me check I have this right...") to confirm accuracy. End by asking, "Is there anything else you think I should know?" and "What are you most worried this might be?" The second question often reveals a fear (cancer, paralysis, losing a job) that shapes the patient's recovery.

TechniqueExampleWhen to use it
Open ended question"Tell me about your back."Opening the history; exploring the patient's perspective
Focused question"What makes the leg pain worse?"Characterizing a symptom
Closed question"Have you had any fever?"Red flag screening, ROS, confirming details
Clarification"When you say numb, do you mean you cannot feel touch, or that it tingles?"Vague or ambiguous terms (dizzy, numb, weak)
Summarizing"So the pain started after lifting, goes to your left foot and is worse sitting?"Checking accuracy and showing you listened
Empathic statement"That sounds very frightening."Emotional content; builds trust and disclosure
Leading question (avoid)"You haven't had any bladder trouble, have you?"Never: it invites the answer you suggested

Clarifying vague terms

Patients use words that mean different things to different people. Dizziness may be vertigo (a spinning illusion, vestibular or brainstem), presyncope (near fainting, cardiovascular or orthostatic), disequilibrium (unsteadiness on the feet, neurologic or proprioceptive) or vague lightheadedness (often anxiety or medication). Numbness may mean loss of sensation, tingling or a feeling of heaviness. Weakness may mean true loss of strength, fatigue or pain inhibition.

Special populations

PopulationAdaptations to the historyDiagnoses to keep in mind
Infants and young childrenHistory from the parent or caregiver; birth history, milestones, feeding, sleep; ask the child directly when old enough; watch for inconsistent storiesInfection, leukemia, neuroblastoma, discitis (refusal to walk), nonaccidental injury; back pain under 10 years is rarely mechanical
AdolescentsInterview partly without the parent where appropriate; sport, growth spurt, school, moodSpondylolysis, Scheuermann disease, scoliosis, slipped capital femoral epiphysis (knee or groin pain), osteoid osteoma, Ewing sarcoma, osteosarcoma
Older adultsAllow more time; check hearing and vision; involve family with consent; full medication list (polypharmacy); falls history; cognitive screen if memory is uncertainOsteoporotic fracture, malignancy, stenosis, AAA, polymyalgia rheumatica, giant cell arteritis, elder abuse
Pregnant patientsGestational age, obstetric history, complications; ask about bleeding, contractions, fluid leakage, headache and visual changePregnancy related pelvic girdle pain; must not miss preterm labor, placental abruption, preeclampsia (headache, epigastric pain, visual change, edema), DVT, pyelonephritis
Non-English speakingUse a trained medical interpreter (in person, phone or video); speak to the patient, not the interpreter; short sentences; confirm understanding with teach back; document the interpreter's name or IDMissed red flags from miscommunication; cultural differences in describing pain
Hearing impairedFace the patient, good lighting, written questions, sign language interpreterAs for the general population
Cognitive impairmentSimple questions, caregiver input, observe behavior (grimacing, guarding) as pain indicatorsDelirium from infection or medication; occult fracture after falls

Interpreters

Family members, and especially children, should not interpret a clinical history except in an emergency: they may filter or omit sensitive information (bladder, sexual or abuse history), lack medical vocabulary and compromise confidentiality. A trained medical interpreter translates exactly and keeps confidentiality. Speak in the first person directly to the patient, and document the language and the interpreter's name or ID, using the same approach for informed consent.

The pregnant patient

Low back and pelvic girdle pain affect more than half of pregnant women, and most is mechanical, related to relaxin mediated ligamentous laxity, weight gain, an anterior shift of the center of gravity and increased lumbar lordosis. The history must still screen for obstetric emergencies. Rhythmic low back pain that comes and goes with tightening of the abdomen may be preterm labor. Vaginal bleeding with constant abdominal or back pain and a rigid uterus suggests placental abruption. Headache, visual disturbance, right upper quadrant or epigastric pain and sudden swelling after 20 weeks suggest preeclampsia; check blood pressure. Fever with flank pain suggests pyelonephritis, which is more common in pregnancy. Unilateral calf pain and swelling suggests DVT, whose risk is several times higher in pregnancy and the postpartum period. In the first trimester, unilateral pelvic pain with spotting raises ectopic pregnancy.

S: Subjective (the history) Chief complaint in the patient's words, with duration HPI: onset, mechanism, OPQRST, prior care and response Past history, surgeries, medications, allergies Family history, occupation, habits, sleep, stress ROS with pertinent negatives recorded: "Denies bladder or bowel change, saddle numbness, fever" Baseline outcome measures: pain scale, Oswestry or NDI, patient goals O: Objective Vitals, exam, tests, imaging and lab results A: Assessment Diagnosis, differential, red flags addressed P: Plan Care, consent, goals, referral, reassessment
Figure 1.5 Where the history sits in a SOAP note. The subjective section carries the chief complaint, the HPI, the background history, the review of systems with pertinent negatives and the baseline outcome measures; everything in the assessment and plan should trace back to it.

Documenting the history in a defensible record

The record is a clinical, legal and billing document. It must allow another clinician to understand what you found, what you thought and why you did what you did. A defensible history has these features:

Case. A 35 year old woman at 28 weeks of pregnancy reports low back pain for two weeks that she thought was "normal pregnancy pain." Over the last day it has become rhythmic, coming every 10 minutes with a tightening of her abdomen, and she has noticed a watery discharge.
Reasoning: Rhythmic back pain with uterine tightening and possible rupture of membranes at 28 weeks is preterm labor until proven otherwise. The correct action is immediate referral to labor and delivery (or emergency services), not treatment of the back. Document the time, symptoms, the advice given and the patient's response. The lesson is that pregnancy related mechanical pain is a diagnosis made only after the obstetric red flags have been asked about.
Board tip. Questions about documentation usually test three ideas: record pertinent negatives for red flags; correct errors with a single line, date and initials, never by erasing; and use a trained interpreter, not a family member or child, with the interpreter's identity documented.
Key point

Good communication produces better histories: open questions first, then focused and closed questions, with vague words clarified and no leading questions. Adapt the history to children, older adults, pregnant patients and patients who need an interpreter, and document it so that another clinician, a reviewer or a court can see what was asked, what was found and why the plan followed.

The chapter in one breath

  • The history makes most diagnoses; it sorts patients into serious pathology, radicular syndrome and nonspecific mechanical pain.
  • OPQRST and OLDCARTS organize the HPI; onset and mechanism of injury predict the injured tissue and the risk of fracture.
  • Flexion intolerance with cough aggravation suggests disc; extension intolerance suggests facet or stenosis; relief by sitting and bending forward is neurogenic claudication.
  • Background history sets pretest probability: prior cancer (LR+ about 15), steroids, anticoagulants, injection drug use, smoking and family history of spondyloarthritis or aneurysm all reshape the differential.
  • The review of systems uncovers systemic and visceral disease; visceral pain does not behave mechanically and relates to organ function.
  • Ask every spinal patient the red flag questions for cancer, infection, fracture, cauda equina syndrome (urinary retention, saddle numbness) and vascular disease, and document the negatives.
  • Before neck care, screen for cervical artery dissection: sudden unusual neck pain or headache and the 5 Ds and 3 Ns.
  • Yellow flags (fear avoidance, catastrophizing, low mood, work and compensation issues) predict chronicity; screen with tools such as STarT Back.
  • The two key branch points are mechanical versus nonmechanical behavior and radicular versus somatic referred distribution.
  • Guard against anchoring, premature closure and confirmation bias by always naming a must not miss alternative.
  • Use open questions first, clarify vague terms, avoid leading questions, and use a trained medical interpreter, never a child.
  • A defensible record is contemporaneous, includes pertinent negatives and baseline outcome measures, and is corrected only by a single line with date and initials.

Words worth knowing

TermWhat it means
Chief complaintThe main reason for the visit, recorded in the patient's own words with its duration.
History of present illnessThe detailed chronological account of the current complaint, usually organized with OPQRST or OLDCARTS.
OPQRSTMnemonic for the HPI: onset, provocation and palliation, quality, region and radiation, severity, timing.
Mechanism of injuryThe forces, direction and body position involved in an injury; it predicts which tissue failed.
Review of systemsA structured inventory of symptoms in each body system to uncover problems the patient has not mentioned.
Pertinent negativeThe documented absence of a symptom that would have changed the diagnosis or plan, such as no saddle numbness.
Red flagA history or examination feature that raises the probability of serious disease such as cancer, infection or fracture.
Yellow flagA psychosocial factor, such as fear avoidance or low mood, that predicts persistent pain and disability.
Cauda equina syndromeCompression of multiple lumbosacral roots causing urinary retention, saddle anesthesia, bowel and sexual dysfunction and leg weakness; a surgical emergency.
Mechanical painPain that varies with posture, movement and load and has a position of relief.
Nonmechanical painConstant or progressive pain unaffected by position, often worse at night, suggesting systemic or visceral disease.
Inflammatory back painBack pain with onset before 40, insidious onset, improvement with exercise, no improvement with rest and night pain; typical of axial spondyloarthritis.
Somatic referred painDeep, diffuse pain felt away from a spinal source such as a facet or sacroiliac joint, usually not below the knee, without neurological deficit.
Radicular painSharp, shooting pain in a narrow band from an irritated nerve root, often extending below the knee or elbow.
RadiculopathyObjective loss of nerve root function: dermatomal sensory loss, myotomal weakness or reduced reflex.
MyelopathySpinal cord dysfunction from compression, with bilateral symptoms, clumsy hands, gait change and upper motor neuron signs.
Neurogenic claudicationButtock and leg pain or heaviness on walking from lumbar stenosis, relieved by sitting or bending forward.
Vascular claudicationExercise induced calf or buttock pain from arterial insufficiency, relieved by simply standing still.
Pretest probabilityThe probability that a patient has a condition before a particular test or finding is considered.
Likelihood ratioHow much a finding changes the odds of a diagnosis; above 10 or below 0.1 is a large, often decisive shift.
SnNout and SpPinA negative result on a highly sensitive test helps rule out; a positive result on a highly specific test helps rule in.
AnchoringA cognitive bias of holding onto the first impression despite later contradictory information.
5 Ds and 3 NsBrainstem warning symptoms: dizziness, diplopia, dysarthria, dysphagia, drop attacks, ataxia, nausea, nystagmus, numbness.
Fear avoidanceThe belief that activity will cause harm, leading to avoidance, deconditioning and disability.
STarT Back toolA nine item questionnaire that stratifies low back pain patients into low, medium or high risk of a poor outcome.

Check yourself

A 41 year old man has low back pain and right leg pain for 10 days after lifting. Before beginning the examination, which history question is most important to ask and document?
Whether he has any bladder or bowel change or numbness in the saddle area. With leg symptoms from a probable disc, the cauda equina screen is the question whose answer would change management from conservative care to emergency referral.
A 70 year old man reports calf pain after walking one block that disappears within two minutes when he stands still. He can ride a stationary bike only briefly before the same pain starts. What does the history suggest?
Vascular claudication from peripheral arterial disease. Relief by simply standing still and pain with cycling point to arterial insufficiency; neurogenic claudication needs sitting or flexing and usually allows cycling.
Which single history feature carries the greatest weight for spinal malignancy in a patient with low back pain?
A prior history of cancer. Its positive likelihood ratio is about 15. Age over 50, unexplained weight loss and failure of a month of care add weight, especially in combination.
A 27 year old man has had back pain for a year, with two hours of morning stiffness, improvement after exercise and pain that wakes him in the early morning. What is the most likely diagnosis and what laboratory tests support it?
Axial spondyloarthritis; HLA-B27 and CRP or ESR. The history fits inflammatory back pain. Sacroiliac imaging and rheumatology co-management follow.
A 48 year old woman developed severe right sided neck pain and a headache unlike her usual migraines after a yoga class, and now reports slurred speech and difficulty swallowing. What is the next step?
Immediate emergency referral for suspected vertebral artery dissection. Sudden unusual neck pain and headache with dysarthria and dysphagia are brainstem warning signs. Do not perform provocative tests or treat the neck.
A patient who works in a warehouse believes that bending will "damage his spine for good," has been off work for 10 weeks and has a workers' compensation claim. What category of factor is this and what does it predict?
Yellow flags (with blue and black flag elements); they predict chronic disability and delayed return to work. They call for education, reassurance, graded activity and possibly psychologically informed care, not a search for serious pathology.
A 74 year old woman on long term prednisone has acute midthoracic pain after lifting a laundry basket. What is the most appropriate step before manual therapy?
Thoracic spine radiographs to exclude a compression fracture. Minor trauma, age and corticosteroid use make an osteoporotic fracture likely; thrust techniques are contraindicated until it is excluded.
A clinician concludes "muscle strain" because the patient mentioned gardening and ignores the patient's 7 kg weight loss and constant night pain. Which cognitive error is this?
Anchoring (with premature closure). The first impression was retained despite red flags pointing to nonmechanical, possibly malignant disease.
During history taking you realize a statement in yesterday's note is wrong. How should it be corrected?
Draw a single line through the error so it remains legible, write the correction, and add the date, time and initials. Never erase, obliterate or rewrite the record; additions are labeled as late entries.
A 33 year old woman at 32 weeks of pregnancy has low back pain with a new severe headache, blurred vision and epigastric pain. What must be checked immediately and what is suspected?
Blood pressure; preeclampsia. Headache, visual change and epigastric pain after 20 weeks are warning signs of preeclampsia, which requires same day obstetric evaluation.