The Case History
On Part III, the history is where the case is won or lost: the vignette hands you a few words from the patient, and the item asks what you should ask next, what the answer means and which diagnosis it makes likely. In the clinic the same skill decides whether a patient with back pain gets an adjustment, an x-ray or a same day trip to the emergency department. This chapter teaches you to turn a vague complaint into a focused, defensible history that has already narrowed the differential before you lay a hand on the patient.
By the end of this chapter you can
- Organize the history of present illness with OPQRST and OLDCARTS and explain what each answer suggests about the tissue at fault.
- Use the mechanism of injury and the timeline to predict the injured structure and the likelihood of fracture.
- Explain how past medical, surgical, medication, family and social history raise or lower the probability of specific diagnoses.
- Run a systematic review of systems and ask the exact questions that uncover cancer, infection, fracture, cauda equina syndrome, vascular and visceral causes of spinal pain.
- Recognize yellow flags that predict chronic disability and name the screening tools that measure them.
- Separate mechanical, nonmechanical, inflammatory, radicular and visceral pain patterns from the history alone.
- Apply pretest probability and pattern recognition to build a ranked differential with a must not miss alternative.
- Adapt history taking for pediatric, geriatric, pregnant and non-English speaking patients, including proper use of interpreters.
- Document the history in a clear, defensible record that supports the diagnosis, the plan and informed consent.
Section 1The chief complaint and history of present illness
What the history is for
Studies in primary care have shown for decades that the history alone leads to the correct diagnosis in roughly 70 to 80 percent of patients; the physical examination and tests add comparatively little once a good history is in hand. For a chiropractor the history has three jobs. First, it sorts the patient into one of three diagnostic bins: serious pathology (about 1 to 2 percent of spinal pain patients), radicular syndrome (about 5 to 10 percent) and nonspecific mechanical pain (about 90 percent). Second, it generates a short list of hypotheses that the examination will test. Third, it establishes the baseline against which you will judge progress and on which your record stands if the case is ever reviewed.
The standard order is: identifying data, chief complaint (CC), history of present illness (HPI), past medical history (PMH), medications and allergies, family history (FH), personal and social history (SH), and the review of systems (ROS). Part III items test the logic inside each part: which question best discriminates between two diagnoses, which answer is a red flag, and which piece of history is missing.
The chief complaint
The chief complaint is recorded in the patient's own words, with its duration: "Low back pain going down my left leg for three weeks." It should not be a diagnosis ("sciatica" or "subluxation") because a premature label closes the mind. If a patient has several complaints, list them, ask which matters most, and take a separate HPI for each one, because a new symptom (for example, a headache in a patient who came for neck pain) may have a completely different cause.
OPQRST and OLDCARTS
Both mnemonics cover the same ground. OPQRST is Onset, Provocation and Palliation, Quality, Region and Radiation, Severity, and Timing. OLDCARTS is Onset, Location, Duration, Character, Aggravating factors, Relieving factors, Timing and Severity. What matters on the board is not the acronym but what each answer means.
| Element | Key question | Answer | What it suggests |
|---|---|---|---|
| Onset | How did it start? | Sudden with a specific load (lift and twist) | Mechanical injury: disc, facet, muscle strain |
| Onset | How did it start? | Insidious, no event, steadily worsening | Degenerative, inflammatory, neoplastic or infectious; ask red flag questions |
| Onset | How did it start? | Sudden, severe, "worst ever", no trauma | Vascular (dissection, aneurysm, hemorrhage) until proven otherwise |
| Provocation | What makes it worse? | Sitting, bending, cough, sneeze, strain | Discogenic or radicular (raised intradiscal or intrathecal pressure) |
| Provocation | What makes it worse? | Standing, extension, walking downhill | Facet joint or central or lateral stenosis |
| Palliation | What makes it better? | Lying down, rest, position change | Mechanical pain |
| Palliation | What makes it better? | Nothing; or exercise helps and rest does not | Nonmechanical (tumor, infection, visceral); exercise relief suggests inflammatory spondyloarthritis |
| Quality | What does it feel like? | Deep ache | Somatic (joint, ligament, muscle, annulus) |
| Quality | What does it feel like? | Burning, electric, shooting, pins and needles | Neuropathic or radicular |
| Quality | What does it feel like? | Tearing or ripping | Arterial dissection |
| Region and radiation | Where does it go? | Narrow band below the knee to the foot | Radicular pain (nerve root) |
| Region and radiation | Where does it go? | Diffuse, buttock and thigh, stops above the knee | Somatic referred pain (facet, SI joint, disc) |
| Severity | 0 to 10, and what can you not do? | Rating plus functional loss | Baseline for outcome measures (NPRS, Oswestry, NDI) |
| Timing | When is it worst? | Morning stiffness over 30 to 60 minutes | Inflammatory arthritis |
| Timing | When is it worst? | Night pain, unrelieved by position | Red flag: tumor or infection |
| Timing | When is it worst? | End of day, after activity | Mechanical or degenerative (osteoarthritis) |
Mechanism of injury
The mechanism is the history's best predictor of which tissue failed and whether a fracture is possible. Ask exactly what happened, the forces and their direction, the position of the body, what the patient felt and heard, and what they could do immediately afterward.
- Flexion with rotation under load (lifting a box and turning) concentrates stress on the posterolateral annulus: classic disc injury.
- Axial load (fall from height onto the feet or buttocks, diving into shallow water) produces compression or burst fractures, most often at the thoracolumbar junction (T11 to L2). A calcaneal fracture from a fall onto the heels travels with a lumbar fracture in about 10 percent of cases, so ask about heel pain and examine both.
- Repetitive hyperextension (gymnastics, football linemen, cricket bowlers, divers) stresses the pars interarticularis: spondylolysis in adolescents.
- Acceleration and deceleration in a motor vehicle collision causes whiplash associated disorders. Ask about direction of impact, whether the head was rotated (worse outcome), headrest height, seat belt and airbag, speed, awareness of the impending impact, and whether symptoms began immediately or the next day.
- Fall on an outstretched hand injures the scaphoid, distal radius, radial head and shoulder.
- Minimal trauma (a cough, stepping off a curb, lifting a grandchild) producing sharp thoracic or lumbar pain in an older or steroid treated patient is an osteoporotic compression fracture until proven otherwise.
- No mechanism at all is itself a finding: insidious pain without an event points away from simple strain and toward degenerative, inflammatory, neoplastic or infectious disease.
The timeline
Duration classifies spinal pain as acute (under 6 weeks), subacute (6 to 12 weeks) and chronic (over 12 weeks, or 3 months). The trajectory matters as much as the duration. Most acute mechanical episodes improve substantially within 2 to 6 weeks; a course that is steadily progressive despite rest and appropriate care is a red flag in itself. Ask about previous episodes, because a recurrent pattern of short mechanical episodes with full recovery between them is reassuring, while a first episode at age 55 or later deserves more caution. Ask what treatment has been tried and with what result: failure to improve after about four weeks of appropriate conservative care is a common trigger for imaging or referral.
Aggravating and relieving factors in more depth
The behavior of pain under load is one of the strongest clues to the pain generator. Flexion intolerance (worse with sitting, bending, lifting, driving, getting out of a chair, morning) fits a discogenic source, because flexion loads the anterior column and pushes nuclear material posteriorly. Extension intolerance (worse with standing, walking, lying prone, reaching overhead) fits the facet joints or stenosis, because extension loads the posterior elements and narrows the canal and foramina. Pain that is worse with cough, sneeze or straining (Valsalva) suggests a space occupying lesion that raises intrathecal pressure on a sensitized root, usually a disc herniation but occasionally a tumor. Pain relieved by sitting or flexing forward and brought on by walking, with leg symptoms, is the hallmark of neurogenic claudication from lumbar spinal stenosis, while leg pain on walking that eases with simply standing still suggests vascular claudication.
Worked examples: turning a vague complaint into a focused history
Reasoning: Flexion plus rotation under load, leg pain worse than back pain, pain below the knee in an S1 distribution and cough aggravation make a right L5 to S1 posterolateral disc herniation with S1 radicular pain the leading hypothesis. Your examination is now focused: straight leg raise, slump, S1 myotome (plantarflexion, toe walking), Achilles reflex and lateral foot sensation. The negative cauda equina questions must be documented. Do not stop at "sciatica"; record the dermatome and the absence of red flags.
Reasoning: Relief by flexion (sitting, leaning forward, the "shopping cart sign"), not by simply stopping, and tolerance of cycling point to neurogenic claudication from lumbar spinal stenosis rather than vascular claudication. The must not miss alternative is peripheral arterial disease, so palpate pedal pulses and consider an ankle brachial index. Asking only "Does walking hurt?" would not have separated the two.
The history of present illness turns a vague complaint into a testable hypothesis. Onset and mechanism predict the injured tissue and the risk of fracture; behavior under load separates mechanical from nonmechanical and flexion from extension intolerance; distribution separates somatic referred from radicular pain. A focused history makes the examination short and pointed.
Section 2Past, family, personal and social history
Why the background history matters
The background history changes pretest probability. The same complaint of thoracic pain means one thing in a fit 25 year old rower and something very different in a 70 year old woman on long term prednisone or a 60 year old man treated for prostate cancer five years ago. Each element below should be asked with a purpose: to raise or lower the probability of a specific diagnosis, or to identify a contraindication to a specific treatment.
Past medical and surgical history
- Prior episodes of the same complaint, how they were treated and how they resolved. Recurrent mechanical episodes predict recurrence; previous good response to manipulation predicts a good response again.
- Prior injuries and fractures, including fragility fractures (wrist, hip, vertebra) that indicate osteoporosis.
- Prior spinal surgery (discectomy, laminectomy, fusion, disc replacement), with dates and levels. Fusion and instrumentation alter technique choice; failed back surgery syndrome changes prognosis; recent surgery with new fever or wound drainage suggests postoperative infection.
- Cancer, at any time. A history of cancer is the single strongest history predictor of malignancy as the cause of back pain (positive likelihood ratio roughly 15). The cancers that most often metastasize to bone are breast, prostate, lung, kidney and thyroid.
- Systemic disease: diabetes (neuropathy, infection risk, delayed healing), rheumatoid arthritis (atlantoaxial instability), inflammatory bowel disease and psoriasis (spondyloarthritis), osteoporosis, connective tissue disorders such as Ehlers Danlos and Marfan syndromes (hypermobility, arterial fragility), cardiovascular disease, kidney stones, and any immunosuppression (HIV, transplant, chemotherapy).
- Down syndrome: atlantoaxial instability in about 10 to 20 percent of patients.
Medications and allergies
Medications both reveal hidden diagnoses and change what you can safely do. Ask about prescription drugs, over the counter drugs, supplements and recreational drugs, and record allergies with the type of reaction.
| Medication | Why it matters in the case | Action |
|---|---|---|
| Anticoagulants (warfarin, apixaban, rivaroxaban, dabigatran) and antiplatelets | Bleeding risk: epidural or soft tissue hematoma, bruising with deep soft tissue work | Modify force; avoid high velocity thrust if anticoagulation is unstable; document INR if on warfarin |
| Long term corticosteroids | Osteoporosis, compression fracture, avascular necrosis of the femoral head, infection risk, masked fever | Lower threshold for imaging after minor trauma; gentle, low force techniques |
| Fluoroquinolones (ciprofloxacin, levofloxacin) | Tendinopathy and Achilles rupture, especially with steroids and age over 60 | Ask in any new tendon pain; avoid aggressive loading |
| Statins | Myalgia; rarely myopathy or rhabdomyolysis (dark urine, weakness) | Diffuse muscle pain after starting a statin: refer to prescriber, CK testing |
| NSAIDs | GI bleeding, renal impairment, hypertension; may mask inflammatory symptoms | Ask about black stools and epigastric pain |
| Opioids | Constipation, sedation, dependence; long term use predicts chronicity | Note dose and duration; yellow flag |
| Bisphosphonates, denosumab | Indicate known osteoporosis; rare atypical femoral fracture (thigh pain) | Modify thrust; image new thigh or groin pain |
| Oral contraceptives, estrogen | Venous thromboembolism risk; slight stroke risk | Consider DVT in calf pain and swelling |
| Antihypertensives, diuretics | Orthostatic hypotension, dizziness, cramps (electrolytes) | Rise slowly from the table; consider in dizziness |
| Antidepressants, anticonvulsants (gabapentin) | Indicate depression or neuropathic pain; dizziness | Yellow flag context; fall risk in older adults |
| Isotretinoin, aromatase inhibitors | Arthralgia and myalgia as side effects | Consider drug cause of diffuse pain |
Family history
Family history raises the probability of conditions with a genetic component. A first degree relative with ankylosing spondylitis or other spondyloarthritis, psoriasis or inflammatory bowel disease supports inflammatory back pain (HLA-B27). A family history of abdominal aortic aneurysm raises AAA risk several fold. Family history of premature cardiovascular disease (a male relative under 55 or a female relative under 65) matters in chest, jaw and arm pain. Ask also about cancer (breast, colon, prostate), osteoporosis and hip fracture in a parent (a FRAX risk factor), scoliosis (adolescent idiopathic scoliosis clusters in families), gout, rheumatoid arthritis, diabetes, migraine, connective tissue disorders and sudden cardiac death in a young relative (relevant to athletes).
Personal and social history
| Element | Ask about | How it changes the working diagnosis |
|---|---|---|
| Occupation | Posture, lifting, vibration, repetitive tasks, job satisfaction, time off work | Heavy lifting and whole body vibration (drivers) predict disc disease; keyboard work fits upper crossed syndrome and carpal tunnel; job dissatisfaction is a yellow flag |
| Physical activity and sport | Type, volume, recent change | Recent training increase suggests stress fracture or tendinopathy; hyperextension sports suggest spondylolysis |
| Tobacco | Pack years, current use | Lung cancer (Pancoast tumor with shoulder and C8 to T1 pain), disc degeneration, poor bone and wound healing, PAD, AAA |
| Alcohol | Quantity; CAGE or AUDIT C screening | Pancreatitis (epigastric pain to the back), avascular necrosis, falls, neuropathy, osteoporosis |
| Recreational drugs | Injection drug use | Spinal epidural abscess, vertebral osteomyelitis, endocarditis |
| Sleep | Hours, waking from pain, position | Waking from pain that no position eases is a red flag; poor sleep amplifies pain and predicts chronicity |
| Stress and mood | Life events, depression and anxiety screening (PHQ-2) | Psychological distress predicts chronic disability; muscle tension headache |
| Diet and weight | Recent weight change, calcium and vitamin D, eating disorders | Unexplained weight loss is a red flag; low energy availability in athletes causes stress fractures |
| Sexual and travel history | New partners, recent travel | Reactive arthritis after chlamydia or enteric infection; disseminated gonococcal arthritis; tuberculosis exposure |
| Home and support | Who is at home, stairs, falls | Fall risk and fracture in the elderly; ability to follow a home program |
| Litigation and compensation | Open claims, lawyer involved | A yellow flag for slower recovery, not proof of exaggeration |
How each piece changes the working diagnosis
Think of each answer as a weight on a scale. Age over 50, prior cancer, unexplained weight loss and failure of a month of care push toward malignancy. Fever, injection drug use, recent infection (urinary tract, skin), immunosuppression, diabetes and recent spinal procedures push toward infection. Older age, osteoporosis, steroids and trauma push toward fracture. Age under 40, morning stiffness, alternating buttock pain, uveitis, psoriasis, inflammatory bowel disease and a family history of spondyloarthritis push toward axial spondyloarthritis. Smoking, hypertension, male sex, age over 60 and family history push toward AAA. A young, active, healthy patient with a clear mechanical onset sits firmly at the benign end.
Reasoning: Minimal trauma, older age, long term corticosteroids and a prior fragility fracture make an osteoporotic vertebral compression fracture by far the most likely diagnosis. The next step is radiographs of the thoracic spine before any manual therapy. High velocity thrust to the thoracic spine is contraindicated until fracture is excluded and bone quality is known. Ask also about weight loss and cancer, because a pathologic fracture from myeloma or metastasis is the must not miss alternative.
Reasoning: Onset before 40, insidious onset, improvement with exercise but not rest, night pain improving on getting up, alternating buttock pain, prior anterior uveitis and a suggestive family history make axial spondyloarthritis (ankylosing spondylitis) the leading diagnosis. Order or request HLA-B27, CRP and imaging of the sacroiliac joints, and arrange rheumatology co-management. Treating as simple mechanical back pain would delay disease modifying therapy.
The past, family, personal and social history set the pretest probability of each diagnosis and expose contraindications. Cancer history, steroid use, anticoagulation, injection drug use, smoking and a family history of spondyloarthritis or aneurysm should each reshape the differential and the treatment plan.
Section 3Review of systems and red flag questioning
The systematic review of systems
The review of systems (ROS) is a structured head to toe inventory of symptoms the patient may not connect with the chief complaint. Its purpose in a chiropractic case is to find the patient whose musculoskeletal complaint is really systemic or visceral disease, and the patient who has a second problem that needs attention. A written intake questionnaire covers the ground efficiently; the clinician then asks follow up questions about every positive answer and about the systems most relevant to the complaint.
| System | Key questions | A positive answer may point to |
|---|---|---|
| Constitutional | Fever, chills, night sweats, fatigue, unexplained weight loss (more than about 5 percent in 6 to 12 months) | Cancer, infection, inflammatory disease, endocrine disease |
| Skin | Rash, psoriasis, new or changing moles, bruising | Psoriatic arthritis, melanoma, Lyme disease, bleeding disorder, shingles |
| Head, eyes, ears, nose, throat | Headache pattern, visual loss or double vision, red painful eye, hearing loss, tinnitus, vertigo | Giant cell arteritis, uveitis (spondyloarthritis), vertebrobasilar insufficiency, acoustic neuroma |
| Cardiovascular | Chest pain on exertion, palpitations, leg swelling, calf pain on walking | Angina, arrhythmia, heart failure, DVT, peripheral arterial disease |
| Respiratory | Cough, hemoptysis, dyspnea, pleuritic pain | Lung cancer, pneumonia, pulmonary embolism, pleurisy, tuberculosis |
| Gastrointestinal | Dysphagia, heartburn, nausea, change in bowel habit, black or bloody stools, pain related to meals | Peptic ulcer, pancreatitis, cholecystitis, colorectal cancer, inflammatory bowel disease |
| Genitourinary | Dysuria, frequency, hematuria, flank pain, retention, discharge, menstrual relationship | Pyelonephritis, kidney stone, prostate disease, cauda equina, endometriosis, ectopic pregnancy |
| Musculoskeletal | Other joints, morning stiffness, swelling | Inflammatory arthritis, polymyalgia rheumatica, gout |
| Neurologic | Weakness, numbness, gait change, clumsy hands, falls, seizures, speech or swallowing change | Myelopathy, stroke, multiple sclerosis, peripheral neuropathy |
| Psychiatric | Low mood, loss of interest, anxiety, sleep disturbance, suicidal thoughts | Depression, anxiety; yellow flags |
| Endocrine | Heat or cold intolerance, polyuria, polydipsia | Thyroid disease, diabetes |
| Hematologic and lymphatic | Easy bruising, enlarged nodes, recurrent infections | Leukemia, lymphoma, myeloma |
Red flag questions by category
Red flags are features of the history and examination that raise the probability of serious pathology. Individually most are weak; their value lies in combinations and in the strong ones. Know the question to ask for each threat and the urgency of referral if it is positive.
| Threat | History red flags | Urgency if suspected |
|---|---|---|
| Malignancy | Prior cancer; age over 50; unexplained weight loss; failure to improve after 4 to 6 weeks; constant, progressive pain; night pain unrelieved by position; thoracic pain | Urgent (days) workup; same day if new neurological deficit (metastatic cord compression) |
| Infection (osteomyelitis, discitis, epidural abscess) | Fever or chills; injection drug use; immunosuppression; diabetes; recent UTI, skin infection or spinal procedure; constant pain | Same day medical evaluation; emergency if neurological signs |
| Fracture | Significant trauma (or minor trauma in the elderly); osteoporosis; long term steroids; age over 70 | Image before manual therapy; emergency if unstable or neurological deficit |
| Cauda equina syndrome | Urinary retention or new incontinence; saddle (perineal) numbness; fecal incontinence; bilateral or progressive leg weakness or sciatica; sexual dysfunction | Emergency: same day emergency department for MRI and surgical decompression |
| Abdominal aortic aneurysm | Age over 60, male, smoker, hypertension; deep, boring or tearing back or abdominal pain unrelated to movement; pulsatile abdominal mass | Emergency if symptomatic or unstable; known small aneurysm needs vascular follow up |
| Cervical artery dissection | Sudden severe unusual neck pain or headache, often after minor trauma; dizziness, diplopia, dysarthria, dysphagia, drop attacks, ataxia, nausea, nystagmus, numbness (the 5 Ds and 3 Ns); Horner syndrome | Emergency: stroke pathway |
| Myelopathy | Clumsy hands, dropping things, unsteady gait, bilateral paresthesias, bladder change | Urgent referral; emergency if rapidly progressive |
| Visceral disease | Pain unchanged by movement; related to eating, urination or menstruation; associated systemic or organ symptoms | Depends on organ: same day for suspected ectopic pregnancy, MI, pancreatitis, pyelonephritis |
| Inflammatory arthritis | Age under 40, morning stiffness over 30 minutes, better with exercise, uveitis, psoriasis, IBD | Routine to soon rheumatology co-management |
| Giant cell arteritis | Age over 50, new headache, scalp tenderness, jaw claudication, visual disturbance, polymyalgia symptoms | Same day: risk of permanent blindness |
Cauda equina syndrome: the questions you must ask
Cauda equina syndrome results from compression of multiple lumbosacral roots below the conus medullaris, most often by a large central disc herniation at L4 to L5 or L5 to S1, less often by tumor, abscess, hematoma or severe stenosis. The single most sensitive finding is urinary retention (sensitivity about 90 percent); with retention, overflow incontinence follows. Ask every patient with back pain and leg symptoms, in plain words: "Have you had any trouble starting or stopping your urine, or any leaking?" "Any numbness between your legs or around your back passage, for example when you wipe after the toilet?" "Any change in bowel control?" "Any new problem with sexual function?" "Is the leg pain on both sides, or getting worse?" Document both positive and negative answers. Incomplete cauda equina syndrome (altered urinary sensation, reduced saddle sensation, retained control) carries a much better outcome after decompression than the retention stage, which is why the question must be asked early and the patient told to return immediately if any of these symptoms appear.
Vascular and visceral causes from the history
Visceral pain refers to the spine through shared segmental innervation, and its giveaway is that it does not behave mechanically: posture, movement and palpation do not reproduce it, while eating, urination, menstruation or exertion do. Kidney stones cause colicky flank pain radiating to the groin, with restlessness (the patient cannot get comfortable, in contrast to the stillness of mechanical pain) and hematuria. Pyelonephritis adds fever and dysuria. Pancreatitis gives boring epigastric pain through to the back, eased by leaning forward, often after alcohol or a fatty meal. Peptic ulcer on the posterior duodenal wall gives midthoracic pain related to meals. Gallbladder disease refers to the right scapula after fatty meals. Myocardial ischemia refers to the left arm, jaw, neck and interscapular region with exertion, sweating and dyspnea. Aortic dissection causes sudden tearing chest or interscapular pain. Gynecologic disease (endometriosis, ovarian cyst, ectopic pregnancy) causes low back and pelvic pain related to the menstrual cycle; in any woman of reproductive age with low abdominal or back pain, ask the date of the last menstrual period.
Cervical red flags and the vertebrobasilar screen
Before treating the neck, ask about the features of cervical artery dissection and vertebrobasilar insufficiency: recent onset of severe, unusual neck pain or occipital headache (often described as different from any previous headache), especially after minor trauma, sport or prolonged neck extension; and the brainstem symptoms summarized as the 5 Ds and 3 Ns: dizziness, diplopia, dysarthria, dysphagia, drop attacks, ataxia of gait, nausea, nystagmus and numbness (often facial or perioral). Internal carotid dissection may produce an ipsilateral Horner syndrome (ptosis, miosis, anhidrosis) and pulsatile tinnitus. A thunderclap headache (maximal within a minute) suggests subarachnoid hemorrhage. Also ask about features of upper cervical instability: rheumatoid arthritis, Down syndrome, recent trauma, a sense that the head is heavy or unstable, and bilateral paresthesias.
Reasoning: New, severe, unusual neck pain and headache after minor rotation, followed by brainstem symptoms (diplopia, ataxia), is the classic picture of vertebral artery dissection. This is an emergency: do not examine with provocative positional tests and do not treat the neck; arrange immediate transfer to the emergency department for vascular imaging (CT angiography or MR angiography). Document the time and the advice given.
Yellow flags: predicting chronicity
Yellow flags are psychosocial factors that predict persistent pain and disability rather than serious disease. They include fear avoidance beliefs (the belief that movement or work will cause harm), catastrophizing, low mood and depression, anxiety, passive coping (waiting to be fixed), poor sleep, social withdrawal, job dissatisfaction and conflict at work, compensation and litigation issues, and a history of long time off work. Related color flags include blue flags (the worker's perception of the workplace) and black flags (system or contextual barriers such as employer policy or the compensation system). Orange flags denote psychiatric disorders such as major depression or personality disorder that require referral.
| Tool | What it measures | How it is used |
|---|---|---|
| STarT Back Screening Tool | Nine items stratifying low, medium or high risk of poor outcome in low back pain | Matches treatment intensity to risk; high risk patients need psychologically informed care |
| Fear Avoidance Beliefs Questionnaire (FABQ) | Fear avoidance for physical activity and work | High work subscale predicts delayed return to work |
| Pain Catastrophizing Scale | Rumination, magnification, helplessness | Identifies catastrophizing as a treatment target |
| Orebro Musculoskeletal Pain Questionnaire | Broad psychosocial risk of long term disability | Screening in workers with spinal pain |
| PHQ-2 and PHQ-9 | Depression | Two question screen; refer positive and any suicidal ideation |
| Oswestry Disability Index, Neck Disability Index | Function in low back or neck pain | Outcome tracking; a 10 point change is a common clinically important difference on the Oswestry |
The review of systems finds the systemic and visceral disease that hides behind musculoskeletal complaints. Ask the red flag questions for cancer, infection, fracture, cauda equina syndrome, vascular and visceral disease in every spinal patient and document the answers; screen yellow flags in everyone, because they predict who will become chronic.
Section 4Building differential diagnoses from the history
From pattern recognition to probability
Experienced clinicians reason in two modes. Pattern recognition (fast, intuitive) matches the story to an illness script stored from experience: "young man, lift and twist, leg pain below the knee worse with sitting: disc." Analytical reasoning (slow, deliberate) lists possibilities systematically and weighs evidence for each. Pattern recognition is efficient but vulnerable to cognitive biases; analytic reasoning is the check on it. Good practice is to form an early hypothesis from the pattern and then deliberately ask, "What else could this be, and what must I not miss?"
Pretest probability is the probability of a diagnosis before a test is performed, and it comes chiefly from prevalence in the setting and from the history. A test result moves probability, and the size of that move is captured by the likelihood ratio (LR). A positive LR above 10 or a negative LR below 0.1 produces a large, often decisive shift; LRs of 2 to 5 (or 0.2 to 0.5) produce small but sometimes important shifts; an LR near 1 changes nothing. Every history question is a test in this sense. A history of cancer in a back pain patient carries a positive LR near 15; age over 50 alone carries a positive LR near 2.7; "pain not relieved by bed rest" has an LR barely above 1. A highly sensitive finding, when absent, helps rule a condition out (SnNout); a highly specific finding, when present, helps rule it in (SpPin).
Mechanical versus nonmechanical pain
The first branch point in any spinal differential is whether the pain is mechanical. Mechanical pain changes with posture, movement and load, has a position of relief, can be reproduced on examination, and usually follows a recognizable onset. Morning stiffness is brief (under 30 minutes). Nonmechanical pain is constant or progressive, does not change with position, is often worse at night, and is accompanied by systemic or organ specific symptoms. Nonmechanical pain has three broad sources: systemic disease (tumor, infection, inflammatory arthritis, metabolic bone disease), visceral referral and neuropathic or central pain. A mixed picture is common, for example a mechanical overlay on a metastatic lesion, so a mechanical component never excludes serious disease when red flags are present.
| Presentation | Key clue in the history | Most likely diagnosis | Must not miss alternative |
|---|---|---|---|
| Acute low back pain after lifting, no leg pain | Clear mechanical onset, eased by rest | Nonspecific mechanical low back pain (strain, facet, annular) | Compression fracture in older or steroid treated patient |
| Back and leg pain below knee, worse sitting and coughing | Dermatomal radiation, leg worse than back | Lumbar disc herniation with radiculopathy | Cauda equina syndrome; tumor if constant and progressive |
| Older adult, leg pain on walking, eased by sitting and bending | Flexion relief, shopping cart sign | Lumbar spinal stenosis (neurogenic claudication) | Peripheral arterial disease |
| Young adult, morning stiffness, better with exercise | Inflammatory profile, uveitis or psoriasis | Axial spondyloarthritis | Infection (discitis) if fever |
| Adolescent athlete, extension pain | Repetitive hyperextension sport | Spondylolysis | Osteoid osteoma (night pain relieved by aspirin or NSAIDs) |
| Older smoker, deep constant back and abdominal pain | Not changed by movement, vascular risk | Abdominal aortic aneurysm | Pancreatic cancer, retroperitoneal disease |
| Thoracic pain with night pain and weight loss | Nonmechanical, constitutional symptoms | Metastatic disease or myeloma | Infection; aortic disease |
| Fever, constant back pain, injection drug use | Infectious risk factors | Vertebral osteomyelitis or epidural abscess | Endocarditis with septic emboli |
| Flank pain to groin, restless, hematuria | Colicky, cannot get comfortable | Ureteral calculus | AAA (can mimic renal colic in older men) |
| Neck pain, clumsy hands, unsteady gait | Bilateral, upper motor neuron symptoms | Cervical spondylotic myelopathy | Multiple sclerosis, cord tumor |
| Arm pain into thumb, worse with neck extension | Dermatomal, positional | C6 radiculopathy | Pancoast tumor (smoker, C8 to T1, Horner) |
| Widespread pain, fatigue, poor sleep, tender points | Diffuse, nonanatomical, chronic | Fibromyalgia | Hypothyroidism, polymyalgia rheumatica, inflammatory arthritis |
Radicular, referred and central patterns
Separating the distribution of pain is the second branch point. Somatic referred pain arises from a spinal structure (facet joint, disc, sacroiliac joint, muscle) and is felt as a deep, diffuse, poorly localized ache in the same segmental territory, usually not below the knee in the lower limb or below the elbow in the upper. Radicular pain arises from an irritated nerve root and is sharp, shooting or burning, felt in a narrow band, often extends below the knee into the foot, and is usually worse in the limb than in the back. Radiculopathy is the objective loss of root function (dermatomal sensory loss, myotomal weakness, reduced reflex). Myelopathy is cord compression with bilateral symptoms, clumsy hands, gait disturbance and upper motor neuron signs. Visceral referred pain follows the dermatomes of the organ's sympathetic afferents (heart to T1 to T4 and the left arm; gallbladder to the right scapula; kidney to the flank and groin; pancreas to the upper lumbar region). Nociplastic pain (central sensitization) is widespread, disproportionate, with allodynia and hyperalgesia.
Avoiding cognitive traps
- Anchoring: locking onto the first impression (the patient said "I pulled something") and discounting later contradicting facts (weight loss, night pain).
- Premature closure: stopping the search once one plausible diagnosis is found. A disc herniation and a prostate cancer metastasis can coexist.
- Availability bias: overweighting diagnoses seen recently or vividly.
- Confirmation bias: asking only questions that support the favored hypothesis. Deliberately ask a question that would disprove it.
Reasoning: The patient's anchor is gardening, but the history is nonmechanical: constant pain unchanged by position, night pain, weight loss, age over 50 and heavy smoking. The leading considerations are metastatic disease (lung, prostate), multiple myeloma and an abdominal aortic aneurysm, with pancreatic cancer also possible. Before examining, the history already demands abdominal palpation for a pulsatile mass, a neurological screen, radiographs, and laboratory tests (CBC, ESR or CRP, calcium, alkaline phosphatase, PSA, serum protein electrophoresis) or prompt medical referral. Manipulation is deferred until serious disease is excluded.
Reasoning: Colicky pain radiating from flank to groin, restlessness, nausea and hematuria, unaffected by spinal movement, point to a right ureteral calculus. Ask about fever and dysuria (an infected obstructed kidney is an emergency) and the last menstrual period (ectopic pregnancy is the must not miss alternative in a woman of reproductive age). Refer the same day for urinalysis, pregnancy test and imaging; this is not a chiropractic lesion.
A good history yields a ranked differential before the examination begins: a leading diagnosis from pattern recognition, a must not miss alternative from red flags, and the specific examination findings that will separate them. Mechanical versus nonmechanical behavior and radicular versus referred distribution are the two most useful branch points, and pretest probability decides how hard to look.
Section 5Communication, special populations and documentation of the history
Asking questions well
Begin with open ended questions ("Tell me about the pain," "What brings you in today?") and allow the patient to speak without interruption for the first minute or two; most patients finish their opening statement in under two minutes, and interrupting early loses information. Then narrow with focused questions ("Where exactly does it go?") and finish with closed questions that confirm or exclude specific features ("Any numbness between your legs?"). Avoid leading questions ("The pain doesn't go down your leg, does it?") and compound questions that ask two things at once. Use facilitation (nodding, "go on"), clarification ("What do you mean by dizzy: is the room spinning, or do you feel faint?"), reflection and summarizing ("Let me check I have this right...") to confirm accuracy. End by asking, "Is there anything else you think I should know?" and "What are you most worried this might be?" The second question often reveals a fear (cancer, paralysis, losing a job) that shapes the patient's recovery.
| Technique | Example | When to use it |
|---|---|---|
| Open ended question | "Tell me about your back." | Opening the history; exploring the patient's perspective |
| Focused question | "What makes the leg pain worse?" | Characterizing a symptom |
| Closed question | "Have you had any fever?" | Red flag screening, ROS, confirming details |
| Clarification | "When you say numb, do you mean you cannot feel touch, or that it tingles?" | Vague or ambiguous terms (dizzy, numb, weak) |
| Summarizing | "So the pain started after lifting, goes to your left foot and is worse sitting?" | Checking accuracy and showing you listened |
| Empathic statement | "That sounds very frightening." | Emotional content; builds trust and disclosure |
| Leading question (avoid) | "You haven't had any bladder trouble, have you?" | Never: it invites the answer you suggested |
Clarifying vague terms
Patients use words that mean different things to different people. Dizziness may be vertigo (a spinning illusion, vestibular or brainstem), presyncope (near fainting, cardiovascular or orthostatic), disequilibrium (unsteadiness on the feet, neurologic or proprioceptive) or vague lightheadedness (often anxiety or medication). Numbness may mean loss of sensation, tingling or a feeling of heaviness. Weakness may mean true loss of strength, fatigue or pain inhibition.
Special populations
| Population | Adaptations to the history | Diagnoses to keep in mind |
|---|---|---|
| Infants and young children | History from the parent or caregiver; birth history, milestones, feeding, sleep; ask the child directly when old enough; watch for inconsistent stories | Infection, leukemia, neuroblastoma, discitis (refusal to walk), nonaccidental injury; back pain under 10 years is rarely mechanical |
| Adolescents | Interview partly without the parent where appropriate; sport, growth spurt, school, mood | Spondylolysis, Scheuermann disease, scoliosis, slipped capital femoral epiphysis (knee or groin pain), osteoid osteoma, Ewing sarcoma, osteosarcoma |
| Older adults | Allow more time; check hearing and vision; involve family with consent; full medication list (polypharmacy); falls history; cognitive screen if memory is uncertain | Osteoporotic fracture, malignancy, stenosis, AAA, polymyalgia rheumatica, giant cell arteritis, elder abuse |
| Pregnant patients | Gestational age, obstetric history, complications; ask about bleeding, contractions, fluid leakage, headache and visual change | Pregnancy related pelvic girdle pain; must not miss preterm labor, placental abruption, preeclampsia (headache, epigastric pain, visual change, edema), DVT, pyelonephritis |
| Non-English speaking | Use a trained medical interpreter (in person, phone or video); speak to the patient, not the interpreter; short sentences; confirm understanding with teach back; document the interpreter's name or ID | Missed red flags from miscommunication; cultural differences in describing pain |
| Hearing impaired | Face the patient, good lighting, written questions, sign language interpreter | As for the general population |
| Cognitive impairment | Simple questions, caregiver input, observe behavior (grimacing, guarding) as pain indicators | Delirium from infection or medication; occult fracture after falls |
Interpreters
Family members, and especially children, should not interpret a clinical history except in an emergency: they may filter or omit sensitive information (bladder, sexual or abuse history), lack medical vocabulary and compromise confidentiality. A trained medical interpreter translates exactly and keeps confidentiality. Speak in the first person directly to the patient, and document the language and the interpreter's name or ID, using the same approach for informed consent.
The pregnant patient
Low back and pelvic girdle pain affect more than half of pregnant women, and most is mechanical, related to relaxin mediated ligamentous laxity, weight gain, an anterior shift of the center of gravity and increased lumbar lordosis. The history must still screen for obstetric emergencies. Rhythmic low back pain that comes and goes with tightening of the abdomen may be preterm labor. Vaginal bleeding with constant abdominal or back pain and a rigid uterus suggests placental abruption. Headache, visual disturbance, right upper quadrant or epigastric pain and sudden swelling after 20 weeks suggest preeclampsia; check blood pressure. Fever with flank pain suggests pyelonephritis, which is more common in pregnancy. Unilateral calf pain and swelling suggests DVT, whose risk is several times higher in pregnancy and the postpartum period. In the first trimester, unilateral pelvic pain with spotting raises ectopic pregnancy.
Documenting the history in a defensible record
The record is a clinical, legal and billing document. It must allow another clinician to understand what you found, what you thought and why you did what you did. A defensible history has these features:
- Legible, dated and signed (or authenticated in the electronic record), written at the time of the visit or promptly after.
- Chief complaint in the patient's words with duration; HPI with each OPQRST element; mechanism of injury with specific details (for a collision: direction, speed estimate, seat belt, head position, onset of symptoms).
- Pertinent negatives: "Denies saddle anesthesia, bladder or bowel dysfunction, fever, weight loss, night pain." If it is not written, a reviewer will assume it was not asked.
- Baseline functional status and outcome measures (pain scale, Oswestry or Neck Disability Index, activities the patient cannot do) and the patient's goals, which justify the plan and later demonstrate medical necessity.
- Medications and allergies and relevant comorbidities that modify care.
- Objective, nonjudgmental language: record what the patient said in quotation marks rather than labels such as "malingerer" or "drug seeker."
- Corrections made by a single line through the original entry with the date, time and initials, never by obliterating or rewriting; late entries labeled as such with the current date. Altering a record after a complaint or claim is one of the most damaging things a clinician can do.
- Communication with others (phone calls, referrals, advice to go to the emergency department, refusals) with time and content.
Reasoning: Rhythmic back pain with uterine tightening and possible rupture of membranes at 28 weeks is preterm labor until proven otherwise. The correct action is immediate referral to labor and delivery (or emergency services), not treatment of the back. Document the time, symptoms, the advice given and the patient's response. The lesson is that pregnancy related mechanical pain is a diagnosis made only after the obstetric red flags have been asked about.
Good communication produces better histories: open questions first, then focused and closed questions, with vague words clarified and no leading questions. Adapt the history to children, older adults, pregnant patients and patients who need an interpreter, and document it so that another clinician, a reviewer or a court can see what was asked, what was found and why the plan followed.
The chapter in one breath
- The history makes most diagnoses; it sorts patients into serious pathology, radicular syndrome and nonspecific mechanical pain.
- OPQRST and OLDCARTS organize the HPI; onset and mechanism of injury predict the injured tissue and the risk of fracture.
- Flexion intolerance with cough aggravation suggests disc; extension intolerance suggests facet or stenosis; relief by sitting and bending forward is neurogenic claudication.
- Background history sets pretest probability: prior cancer (LR+ about 15), steroids, anticoagulants, injection drug use, smoking and family history of spondyloarthritis or aneurysm all reshape the differential.
- The review of systems uncovers systemic and visceral disease; visceral pain does not behave mechanically and relates to organ function.
- Ask every spinal patient the red flag questions for cancer, infection, fracture, cauda equina syndrome (urinary retention, saddle numbness) and vascular disease, and document the negatives.
- Before neck care, screen for cervical artery dissection: sudden unusual neck pain or headache and the 5 Ds and 3 Ns.
- Yellow flags (fear avoidance, catastrophizing, low mood, work and compensation issues) predict chronicity; screen with tools such as STarT Back.
- The two key branch points are mechanical versus nonmechanical behavior and radicular versus somatic referred distribution.
- Guard against anchoring, premature closure and confirmation bias by always naming a must not miss alternative.
- Use open questions first, clarify vague terms, avoid leading questions, and use a trained medical interpreter, never a child.
- A defensible record is contemporaneous, includes pertinent negatives and baseline outcome measures, and is corrected only by a single line with date and initials.
Words worth knowing
| Term | What it means |
|---|---|
| Chief complaint | The main reason for the visit, recorded in the patient's own words with its duration. |
| History of present illness | The detailed chronological account of the current complaint, usually organized with OPQRST or OLDCARTS. |
| OPQRST | Mnemonic for the HPI: onset, provocation and palliation, quality, region and radiation, severity, timing. |
| Mechanism of injury | The forces, direction and body position involved in an injury; it predicts which tissue failed. |
| Review of systems | A structured inventory of symptoms in each body system to uncover problems the patient has not mentioned. |
| Pertinent negative | The documented absence of a symptom that would have changed the diagnosis or plan, such as no saddle numbness. |
| Red flag | A history or examination feature that raises the probability of serious disease such as cancer, infection or fracture. |
| Yellow flag | A psychosocial factor, such as fear avoidance or low mood, that predicts persistent pain and disability. |
| Cauda equina syndrome | Compression of multiple lumbosacral roots causing urinary retention, saddle anesthesia, bowel and sexual dysfunction and leg weakness; a surgical emergency. |
| Mechanical pain | Pain that varies with posture, movement and load and has a position of relief. |
| Nonmechanical pain | Constant or progressive pain unaffected by position, often worse at night, suggesting systemic or visceral disease. |
| Inflammatory back pain | Back pain with onset before 40, insidious onset, improvement with exercise, no improvement with rest and night pain; typical of axial spondyloarthritis. |
| Somatic referred pain | Deep, diffuse pain felt away from a spinal source such as a facet or sacroiliac joint, usually not below the knee, without neurological deficit. |
| Radicular pain | Sharp, shooting pain in a narrow band from an irritated nerve root, often extending below the knee or elbow. |
| Radiculopathy | Objective loss of nerve root function: dermatomal sensory loss, myotomal weakness or reduced reflex. |
| Myelopathy | Spinal cord dysfunction from compression, with bilateral symptoms, clumsy hands, gait change and upper motor neuron signs. |
| Neurogenic claudication | Buttock and leg pain or heaviness on walking from lumbar stenosis, relieved by sitting or bending forward. |
| Vascular claudication | Exercise induced calf or buttock pain from arterial insufficiency, relieved by simply standing still. |
| Pretest probability | The probability that a patient has a condition before a particular test or finding is considered. |
| Likelihood ratio | How much a finding changes the odds of a diagnosis; above 10 or below 0.1 is a large, often decisive shift. |
| SnNout and SpPin | A negative result on a highly sensitive test helps rule out; a positive result on a highly specific test helps rule in. |
| Anchoring | A cognitive bias of holding onto the first impression despite later contradictory information. |
| 5 Ds and 3 Ns | Brainstem warning symptoms: dizziness, diplopia, dysarthria, dysphagia, drop attacks, ataxia, nausea, nystagmus, numbness. |
| Fear avoidance | The belief that activity will cause harm, leading to avoidance, deconditioning and disability. |
| STarT Back tool | A nine item questionnaire that stratifies low back pain patients into low, medium or high risk of a poor outcome. |