📖 ContentsChapter 13 · Associated Clinical Sciences
Part II Clinical Sciences · Chapter 13 · Associated Clinical Sciences

Geriatrics, Dermatology, Sexually Transmitted Infections, Toxicology and Emergency Care

The associated clinical sciences are where a chiropractor proves to be a primary contact physician rather than a spine technician: the older patient who fell, the mole on the back you see every visit, the young adult whose "back pain" is reactive arthritis, the patient on warfarin who wants a high velocity thrust, and the patient who collapses in the waiting room. Part II tests whether you can recognize these situations, adapt care safely and act correctly in the first minutes of an emergency. This chapter pulls together geriatrics, dermatology, sexually transmitted infections, toxicology and office emergency care, with a constant eye on what must not be missed and when to refer.

By the end of this chapter you can

  • Describe the normal physiology of aging, separate it from disease, and screen older adults for fall risk, osteoporosis, polypharmacy, dementia and delirium.
  • Adapt chiropractic examination and technique for the older adult, including force selection and contraindications.
  • Name and describe primary and secondary skin lesions and recognize common infections, dermatitis, papulosquamous, blistering and pigment disorders.
  • Apply the ABCDE rule and distinguish basal cell carcinoma, squamous cell carcinoma and melanoma.
  • Outline the organisms, presentation and complications of gonorrhea, chlamydia, syphilis, herpes, HPV and HIV, including reactive arthritis, disseminated gonococcal infection and tabes dorsalis.
  • Explain how NSAIDs, opioids, corticosteroids, anticoagulants and other common drug classes change examination findings, risk and treatment choices.
  • Recognize classic poisoning toxidromes and environmental and occupational toxins such as lead, carbon monoxide and organophosphates.
  • Perform the initial response to office emergencies: scene safety, CPR and AED, choking, shock, head and spinal injury, thermal injury and musculoskeletal trauma.
  • Manage syncope, hypoglycemia and anaphylaxis in the office and know when to activate emergency services.

Section 1Geriatrics

The physiology of aging

Aging is a gradual loss of physiologic reserve: organs work adequately at rest but have less capacity to respond to stress. This homeostenosis explains why a minor illness or new drug can tip an older patient into decompensation. Slower memory retrieval is normal; decline that impairs daily function is not.

SystemNormal age related changeClinical consequence
CardiovascularStiffer arteries, rising systolic pressure, reduced beta adrenergic response, lower maximal heart rate (roughly 220 minus age)Isolated systolic hypertension, orthostatic hypotension, reduced exercise tolerance
RespiratoryReduced chest wall compliance and elastic recoil, higher residual volume, lower FEV1Reduced reserve during pneumonia; kyphosis further limits expansion
RenalGlomerular filtration falls (about 1 mL/min per year after age 40 in many people); serum creatinine may stay normal because muscle mass fallsDrug accumulation (NSAIDs, many renally cleared drugs); dehydration risk
MusculoskeletalSarcopenia (loss of muscle mass and strength, type II fibers first), bone loss, disc dehydration, cartilage thinningFalls, fractures, spondylosis, reduced power more than endurance
Nervous systemSlower processing, reduced vibration sense at the ankles, diminished ankle reflexes, slower reaction timeGait and balance problems; an absent ankle jerk alone is not diagnostic
Special sensesPresbyopia, cataract, presbycusis (high frequency hearing loss)Fall risk, communication barriers, social isolation
ImmuneImmunosenescence: weaker T cell responses, reduced fever responseInfections present atypically (confusion, falls) with little or no fever

A practical rule for the older patient is atypical presentation. Myocardial infarction may present as dyspnea or confusion, infection as delirium or a fall, and spinal infection as back pain without fever. Treat a sudden change in function as a symptom in its own right.

Falls

Falls are the leading cause of injury related death and of nonfatal injury in adults over 65. About one in four older adults falls each year, and a fall predicts another fall. Falls result from intrinsic factors (weakness, gait disorder, poor vision, neuropathy, orthostasis, cognitive impairment) and extrinsic factors (medications, lighting, rugs, stairs, footwear). The most modifiable are weakness, balance and medications, especially psychoactive drugs (benzodiazepines, sedative hypnotics, antidepressants, antipsychotics) and antihypertensives that cause orthostasis.

Screen every older patient by asking three questions: have you fallen in the past year, do you feel unsteady when standing or walking, and do you worry about falling? A yes to any prompts a gait, strength and balance assessment.

TestHow it is donePositive findingSuggests
Timed Up and Go (TUG)Patient rises from a standard armchair, walks 3 m (10 feet) at normal pace, turns, walks back and sits12 seconds or longer (some use 13.5 s)Increased fall risk; observe gait quality as well as time
30 second chair standArms crossed, patient stands fully and sits as many times as possible in 30 sBelow the age and sex norm (for example under 12 for ages 65 to 69)Lower limb weakness, fall risk
Romberg testFeet together, arms at sides, eyes open then closedSways or falls with eyes closed but not openProprioceptive (dorsal column or peripheral nerve) deficit
Orthostatic vital signsBlood pressure and pulse supine, then after 1 and 3 minutes standingSystolic drop of 20 mm Hg or more, or diastolic drop of 10 or moreOrthostatic hypotension (volume depletion, drugs, autonomic failure)

Fall prevention is multifactorial: strength and balance training (tai chi has good evidence), medication review, treatment of orthostatic hypotension, vision correction, home hazard modification and footwear.

Clinical link. An older patient who "slipped" but cannot describe the fall, hit the head, takes an anticoagulant, or now has new confusion needs urgent evaluation for subdural hematoma, even days later. Chronic subdural hematoma in the elderly classically presents with fluctuating confusion and headache after a minor fall, because brain atrophy stretches the bridging veins.

Osteoporosis

Osteoporosis is low bone mass with deteriorated microarchitecture and raised fracture risk, defined by DXA of the hip or spine using the T score (comparison with a young adult mean). A T score of −1.0 or higher is normal, between −1.0 and −2.5 is osteopenia, and −2.5 or lower is osteoporosis; a fragility fracture of the hip or spine establishes osteoporosis regardless of T score.

The Z score compares the patient to age and sex matched peers and is used in premenopausal women, men under 50 and children. DXA screening is recommended for all women 65 and older, and FRAX estimates 10 year fracture probability.

Primary osteoporosis is postmenopausal (type I, estrogen loss accelerates trabecular bone resorption, so vertebral and distal radius fractures predominate) or senile (type II, after about 70, cortical and trabecular loss, hip fractures). Secondary causes include glucocorticoid use (the most common drug cause), hyperthyroidism, hyperparathyroidism, hypogonadism, celiac disease, chronic kidney disease, myeloma, alcohol, smoking, anticonvulsants and heparin. Laboratory values (calcium, phosphate, alkaline phosphatase) are normal in uncomplicated osteoporosis, which helps separate it from osteomalacia (low or normal calcium, low phosphate, high alkaline phosphatase, low vitamin D, Looser zones).

The classic presentation is a vertebral compression fracture: sudden midthoracic or thoracolumbar pain after trivial loading (lifting, a cough, bending), loss of height, and progressive thoracic kyphosis. Radiographically, osteoporosis shows generalized radiolucency (about 30 to 50 percent of bone must be lost before it is visible), thinned but sharply defined cortices ("pencil thin" or "picture framing" appearance), prominent vertical trabeculae, and anterior wedge, biconcave ("codfish") or crush deformities. A fracture above T7, a pedicle that is destroyed, or a convex posterior vertebral border raises suspicion of a pathologic fracture from metastasis or myeloma.

Management is shared with medical providers: calcium (about 1,200 mg daily over 50) and vitamin D (800 to 1,000 IU), resistance and balance exercise, fall prevention and drugs. Bisphosphonates (alendronate, risedronate, zoledronic acid) inhibit osteoclasts and are first line (esophagitis; rarely osteonecrosis of the jaw and atypical femoral fracture). Alternatives include denosumab, raloxifene and anabolic agents such as teriparatide.

Osteoporotic vertebral body deformities (lateral view, anterior to the left) Normal Anterior wedge Biconcave Crush heights equal anterior height lossmidthoracic, kyphosis "codfish" endplateslumbar, central loss uniform height losswhole body collapses anterior Thin sharp cortices and accentuated vertical trabeculae accompany the generalized radiolucency.
Figure 13.1 Osteoporotic vertebral deformities. Anterior wedging is typical in the midthoracic spine and drives kyphosis; biconcave "codfish" vertebrae are typical in the lumbar spine. A posterior cortex that bulges or a destroyed pedicle suggests a pathologic fracture instead.
Board tip. Osteoporosis: normal calcium, phosphate and alkaline phosphatase. Osteomalacia: low vitamin D, low phosphate, high alkaline phosphatase and Looser zones (pseudofractures). Paget disease: very high alkaline phosphatase with normal calcium. Hyperparathyroidism: high calcium, low phosphate, subperiosteal resorption on the radial side of the middle phalanges.

Polypharmacy

Polypharmacy is commonly defined as taking five or more medications. Risk of adverse events, interactions, falls and confusion rises with each added drug, and age related declines in renal and hepatic clearance make "normal" doses toxic. A classic hazard is the prescribing cascade: a side effect is mistaken for a new condition and treated with another drug (for example, an NSAID raises blood pressure and an antihypertensive is added, or a calcium channel blocker causes ankle edema and a diuretic is added).

The Beers Criteria list potentially inappropriate medications in older adults. High yield examples are benzodiazepines and sleeping pills, strongly anticholinergic drugs such as diphenhydramine, muscle relaxants such as cyclobenzaprine, and chronic NSAIDs. The chiropractor records every product, including supplements, recognizes likely adverse effects and communicates concerns to the prescriber rather than changing a prescription.

Dementia and delirium

Delirium is an acute, fluctuating disturbance of attention and awareness caused by an underlying medical condition, drug or withdrawal. Dementia is a chronic, progressive decline in cognition severe enough to impair independence. They often coexist, because dementia is the strongest risk factor for delirium. Delirium is a medical emergency with substantial mortality; it is often the first sign of infection, drug toxicity, hypoxia, metabolic derangement, urinary retention, stroke or subdural hematoma.

FeatureDeliriumDementiaDepression
OnsetAcute, hours to daysInsidious, months to yearsWeeks to months, often after a life event
CourseFluctuating, worse at night ("sundowning" overlaps)Slowly progressivePersistent low mood
AttentionMarkedly impaired (hallmark)Normal earlyReduced effort, "I don't know" answers
ReversibilityUsually reversible if the cause is treatedMostly irreversibleTreatable ("pseudodementia")
ActionUrgent medical referral the same dayRoutine referral for evaluation, safety planningReferral, screen for suicide risk

The Confusion Assessment Method (CAM) diagnoses delirium when there is (1) acute onset and fluctuating course and (2) inattention, plus either (3) disorganized thinking or (4) altered level of consciousness. Cognitive screens include the Mini Mental State Examination (MMSE, 30 points; 24 or below suggests impairment), the Montreal Cognitive Assessment (MoCA, 30 points; below 26 suggests impairment, more sensitive for mild cognitive impairment), and the Mini Cog (three word recall plus clock drawing).

The main dementias are Alzheimer disease (most common; early short term memory loss; amyloid plaques, tau tangles and cholinergic loss), vascular dementia (stepwise decline with focal signs), dementia with Lewy bodies (fluctuating cognition, visual hallucinations, parkinsonism, severe antipsychotic sensitivity), frontotemporal dementia (early personality change and disinhibition, younger onset) and normal pressure hydrocephalus (gait disturbance, incontinence and dementia with enlarged ventricles, potentially shunt responsive).

Always consider reversible contributors to cognitive decline: hypothyroidism, vitamin B12 deficiency, depression, drug effects, normal pressure hydrocephalus, chronic subdural hematoma and neurosyphilis.

Adapting chiropractic care for older adults

Adapting care starts with a thorough history and screen for red flags: history of cancer, unexplained weight loss, night pain, fever, new neurologic deficit, steroid use or known osteoporosis, anticoagulation, recent trauma, and symptoms of vascular disease.

Board tip. In the elderly patient with new back pain, the most common serious causes to exclude are osteoporotic compression fracture, metastatic disease (breast, prostate, lung, kidney, thyroid), multiple myeloma (anemia, high ESR, renal failure, hypercalcemia, punched out lesions, often a normal bone scan) and abdominal aortic aneurysm (pulsatile mass, vascular risk factors, men who have smoked).
Key point

Aging reduces reserve, so older patients present atypically and are more vulnerable to falls, fractures, drug effects and delirium. Screen for fall risk and bone fragility, take a full medication list, treat acute confusion as an emergency, and adapt technique toward lower force while keeping red flags for fracture, malignancy and vascular disease at the front of your mind.

Section 2Dermatology

Chiropractors see more bare back skin than almost any other provider, which makes them well placed to notice a changing mole or a rash that signals systemic disease (psoriasis with spondyloarthropathy, a dermatomal eruption of shingles, a palmar rash of secondary syphilis). Describe a lesion by type, size, color, shape, border, arrangement and distribution before naming it.

Primary and secondary lesions

Primary lesions arise directly from the disease process. Secondary lesions develop from evolution of a primary lesion or from scratching, infection or treatment. The size cutoff between small and large lesions is 1 cm in most texts (some use 0.5 cm).

Primary lesionDefinitionExample
MaculeFlat, nonpalpable color change under 1 cmFreckle, flat nevus, petechia
PatchFlat color change 1 cm or largerVitiligo, cafe au lait spot
PapuleSolid, elevated, under 1 cmRaised nevus, wart, lichen planus
PlaqueElevated, flat topped, 1 cm or larger (often merged papules)Psoriasis
NoduleSolid, elevated, deeper and firmer, about 1 to 2 cmLipoma, rheumatoid nodule
TumorSolid mass larger than about 2 cmNeoplasm
VesicleFluid filled, under 1 cmHerpes simplex, varicella, zoster
BullaFluid filled, 1 cm or largerBullous pemphigoid, second degree burn
PustuleElevated, filled with pusAcne, folliculitis
WhealTransient, edematous, pale or red, itchy; resolves within 24 hoursUrticaria (hives)
CystEncapsulated sac with fluid or semisolid contentEpidermoid cyst
TelangiectasiaFine dilated superficial blood vesselsRosacea, basal cell carcinoma, CREST
Secondary lesionDefinitionExample
ScaleFlakes of keratinPsoriasis (silvery), seborrheic dermatitis (greasy)
CrustDried serum, blood or pusImpetigo ("honey colored")
ErosionLoss of epidermis only; heals without scarRuptured vesicle
UlcerLoss into the dermis or deeper; may scarVenous stasis ulcer, chancre
ExcoriationLinear erosion from scratchingScabies, atopic dermatitis
LichenificationThickened skin with accentuated markings from chronic rubbingChronic atopic dermatitis, lichen simplex chronicus
ScarFibrous replacement after dermal injuryHealed wound; keloid if it extends beyond the wound
Primary skin lesions in cross section MaculePapulePlaqueNodule VesicleBullaPustuleWheal flat, under 1 cmraised, under 1 cmraised, flat top, 1 cm+deep, firm, dermal clear fluid, smallclear fluid, 1 cm+pusdermal edema, transient Cream band: epidermis. Pink band: dermis.
Figure 13.2 Primary lesions are named by whether they are flat or raised, solid or fluid filled, and by size. The wheal is transient dermal edema.

Skin infections

ConditionCauseAppearance and features
ImpetigoStaphylococcus aureus, Streptococcus pyogenesHoney colored crusts around nose and mouth in children; bullous form is staphylococcal; very contagious; streptococcal form can precede poststreptococcal glomerulonephritis
CellulitisStrep pyogenes, Staph aureusSpreading warm, red, tender, poorly demarcated area, usually a lower leg; fever; red streaking (lymphangitis) and rapid spread need urgent care
Necrotizing fasciitisGroup A strep or mixed floraPain out of proportion to findings, rapid spread, crepitus, bullae, systemic toxicity; surgical emergency
Verruca (warts)Human papillomavirusRough papules; plantar warts interrupt skin lines and show black dots (thrombosed capillaries) when pared
Herpes zoster (shingles)Reactivated varicella zoster virus in a dorsal root or cranial nerve ganglionBurning pain, then grouped vesicles on a red base in one dermatome, not crossing midline; thoracic most common; postherpetic neuralgia; ophthalmic division involvement threatens vision
Tinea (dermatophytes)Trichophyton, Microsporum, EpidermophytonAnnular scaly plaque with active raised border and central clearing ("ringworm"); named by site: capitis, corporis, cruris, pedis, unguium; KOH prep shows hyphae
ScabiesMite Sarcoptes scabieiIntense nocturnal itch, burrows in finger webs, wrists, waist and genitals; spares the head in adults
Lyme diseaseBorrelia burgdorferi via Ixodes tickErythema migrans: expanding red ring, often with central clearing; later arthritis (knee), Bell palsy, heart block
Clinical link. A patient with unilateral thoracic or rib pain, burning or itching, no mechanical pattern, and no rash yet may have preherpetic zoster; the vesicles appear a few days later along the same dermatome. Before manipulating "intercostal strain" in an older or immunocompromised patient, look at the skin and recheck in a few days. Antiviral treatment works best within 72 hours of rash onset, so refer promptly.

Dermatitis, papulosquamous and blistering disorders

Eczema and dermatitis are near synonyms for inflammation of the epidermis that is itchy, red and, when acute, vesicular and weeping, and when chronic, scaly and lichenified.

DisorderAppearanceDistributionAssociations and signs
PsoriasisWell demarcated red plaques with silvery scaleExtensor surfaces (elbows, knees), scalp, lumbosacral area, gluteal cleftAuspitz sign (pinpoint bleeding when scale removed), Koebner phenomenon (lesions at sites of trauma), nail pitting and onycholysis; psoriatic arthritis (DIP involvement, "pencil in cup", sausage digits, asymmetric sacroiliitis)
Pityriasis roseaSingle "herald patch," then oval salmon colored scaly maculesTrunk in a "Christmas tree" pattern following skin linesSelf limited over 6 to 8 weeks; young adults; mimics secondary syphilis
Bullous pemphigoidTense subepidermal bullae that do not rupture easilyFlexures, trunk; elderlyIgG against hemidesmosomes; Nikolsky sign negative; mouth usually spared
Pemphigus vulgarisFlaccid intraepidermal bullae and erosionsOral mucosa first, then skin; middle ageIgG against desmoglein (desmosomes); Nikolsky sign positive; potentially fatal
Erythema multiformeTarget (iris) lesionsPalms, soles, extremitiesHerpes simplex (most common), mycoplasma, drugs
Stevens Johnson syndrome and TENWidespread painful erythema, blisters, mucosal erosions, skin sloughingUnder 10 percent (SJS) or over 30 percent (TEN) body surfaceDrug reactions (sulfonamides, anticonvulsants, allopurinol, NSAIDs); emergency
Board tip. Nikolsky sign is performed by applying lateral pressure with a finger to normal appearing skin near a blister; it is positive when the epidermis shears away. Positive in pemphigus vulgaris, staphylococcal scalded skin syndrome and toxic epidermal necrolysis; negative in bullous pemphigoid. Pemphigus is intraepidermal and flaccid; pemphigoid is subepidermal and tense.

Pigment disorders

Skin cancer and the ABCDE rule

Skin cancer is the most common cancer. Ultraviolet light is the dominant risk: intermittent blistering sunburns for melanoma and basal cell carcinoma, cumulative exposure for squamous cell carcinoma. Actinic keratosis (rough, sandpaper like scaly papules on sun exposed skin) is a premalignant lesion for squamous cell carcinoma. Seborrheic keratosis is a benign, "stuck on," waxy brown papule of older adults.

FeatureBasal cell carcinomaSquamous cell carcinomaMelanoma
FrequencyMost common skin cancerSecond most commonLess common, most deadly
Cell of originBasal keratinocytesKeratinocytesMelanocytes
Typical siteSun exposed face, especially upper face, noseSun exposed skin, lower lip, ears, dorsum of hands; scars and chronic wounds (Marjolin ulcer)Back in men, legs in women; any site including soles, nails and eye
AppearancePearly, translucent papule with rolled borders and telangiectasias; may ulcerate centrally ("rodent ulcer")Scaly, hyperkeratotic, red papule or plaque that may ulcerate and bleedPigmented lesion that meets the ABCDE criteria or the "ugly duckling" sign
BehaviorLocally invasive, rarely metastasizesCan metastasize, especially lip, ear, immunosuppressedMetastasizes early; prognosis by Breslow depth

The ABCDE rule flags pigmented lesions that need referral for evaluation and biopsy:

LetterFeatureBenign nevusSuspicious for melanoma
AAsymmetryTwo halves matchOne half does not match the other
BBorderSmooth, regularIrregular, notched, ragged or blurred
CColorOne uniform shade of brownSeveral shades (tan, brown, black, red, white, blue)
DDiameterUnder 6 mm6 mm or larger (pencil eraser), though early melanomas can be smaller
EEvolvingStable over timeChanging in size, shape, color, elevation, or new bleeding, itching or crusting
Benign Suspicious ABCDE asymmetrybordercolordiameterevolving halves matchsmooth edgeone shadeunder 6 mmunchanged halves differragged, notchedmany shades6 mm or moregrowing, new color Also refer the "ugly duckling": a mole that looks different from the patient's other moles.
Figure 13.3 The ABCDE rule. Evolution (E) is the most sensitive single feature; any changing pigmented lesion warrants referral to a dermatologist.

Melanoma has four classic subtypes: superficial spreading (most common), nodular (rapid vertical growth, may not fit ABCD), lentigo maligna (sun damaged face of the elderly) and acral lentiginous (palms, soles and nail beds; most common type in darker skin; nail fold pigment is Hutchinson sign). The single most important prognostic factor in localized melanoma is Breslow thickness (depth of invasion in millimeters).

Hair and sebaceous disorders

Acne vulgaris is a disorder of the pilosebaceous unit (androgen driven sebum, follicular plugging, Cutibacterium acnes, inflammation) producing comedones, papules, pustules and cysts; isotretinoin is highly teratogenic. Rosacea gives central facial flushing, telangiectasias and papulopustules without comedones, late rhinophyma. Hidradenitis suppurativa causes recurrent axillary and groin abscesses and sinus tracts and is linked to spondyloarthropathy. Hair loss may be androgenetic (patterned, nonscarring), alopecia areata (autoimmune round patches with "exclamation point" hairs), or telogen effluvium (diffuse shedding months after a stressor). Hirsutism in women most often reflects polycystic ovary syndrome.

Key point

Describe skin findings in precise lesion language first, then match the pattern. Recognize infections that spread or threaten life (cellulitis, necrotizing fasciitis, zoster near the eye), skin signs of systemic and spinal disease (psoriasis, cafe au lait spots, acanthosis nigricans), and use the ABCDE rule and the ugly duckling sign to refer changing moles. Every chiropractor who looks at backs is a skin cancer screener.

Section 3Sexually transmitted infections

Several sexually transmitted infections reach the musculoskeletal and nervous systems: a hot knee or wrist in a young adult, heel pain with low back stiffness, dorsal column ataxia, or sacral radiculitis. Take a respectful, confidential sexual history when the presentation calls for it, refer for testing and treatment, and remember that partners need treatment and that several of these infections are reportable by the diagnosing provider.

Gonorrhea and chlamydia

Both cause urethritis and cervicitis, frequently coexist, and are diagnosed by nucleic acid amplification testing of urine or swabs. Ascending infection in women causes pelvic inflammatory disease (lower abdominal pain, cervical motion tenderness, adnexal tenderness, fever), which can lead to tubal scarring, infertility, ectopic pregnancy and Fitz Hugh Curtis syndrome (perihepatitis with right upper quadrant pain). In men, either can cause epididymitis.

Disseminated gonococcal infection follows bacteremia and is the most common cause of septic arthritis in sexually active young adults. It has two patterns: the arthritis dermatitis syndrome (triad of migratory polyarthralgia, tenosynovitis of the wrist, hand or ankle extensor tendons, and a few painless pustules on the distal limbs) and a purulent monoarthritis, typically the knee, wrist or ankle. Joint cultures are often negative, so mucosal sites are tested; treatment is ceftriaxone.

Reactive arthritis

Reactive arthritis is a sterile inflammatory arthritis that follows a genitourinary infection (chlamydia most often) or an enteric infection (Salmonella, Shigella, Campylobacter, Yersinia) by 1 to 4 weeks. It is a seronegative spondyloarthropathy associated with HLA B27. The classic triad is urethritis, conjunctivitis and arthritis ("can't see, can't pee, can't climb a tree"), but only a minority show all three.

Board tip. In a young adult with a hot knee, the key question is septic versus reactive. Disseminated gonococcal infection: migratory arthralgias, tenosynovitis, pustules, positive mucosal NAAT, and responds to antibiotics. Reactive arthritis: sterile joint, conjunctivitis, enthesitis, HLA B27, weeks after infection, and does not respond to antibiotics. Either needs medical referral; a hot swollen joint should be aspirated.

Syphilis

Treponema pallidum is a spirochete too thin for Gram stain; it is seen by dark field microscopy and diagnosed mainly by serology. Nontreponemal tests (VDRL, RPR) are cheap screening tests whose titers track disease activity but give false positives in pregnancy, lupus and antiphospholipid syndrome. Treponemal tests (FTA ABS, TP PA) confirm infection and usually remain positive for life. Treatment is penicillin G (benzathine penicillin for early disease, intravenous penicillin for neurosyphilis); a fever and myalgia flare after the first dose is the Jarisch Herxheimer reaction.

StageTimingFindings
PrimaryAbout 3 weeks (10 to 90 days)Single painless, clean based, indurated chancre at the inoculation site with painless regional lymphadenopathy; heals in 3 to 6 weeks
SecondaryWeeks to months laterDiffuse maculopapular rash including palms and soles, condylomata lata (moist flat genital lesions), mucous patches, patchy "moth eaten" alopecia, fever, lymphadenopathy, hepatitis, periostitis
LatentEarly (under 1 year) or lateNo signs; positive serology
TertiaryYears to decadesGummas (granulomas of skin, bone, liver), cardiovascular syphilis (ascending aortic aneurysm, aortic regurgitation, "tree bark" intima), neurosyphilis

Neurosyphilis can occur at any stage. Its late forms are classic board material:

Tabes dorsalis: dorsal columns and dorsal roots anterior posterior dorsal root (degenerated) ventral root (spared) gray matter dorsal columns (degenerated) Clinical signs Loss of vibration and position sense Positive Romberg sign Wide based stamping gait Lancinating (lightning) leg pains Absent knee and ankle reflexes Argyll Robertson pupils Neurogenic bladder Charcot joints (knee, hip, spine)
Figure 13.4 In tabes dorsalis the posterior (dorsal) roots and dorsal columns degenerate, so proprioception and vibration are lost while motor function is preserved. Vitamin B12 deficiency produces a similar sensory ataxia but also involves the corticospinal tracts.

Herpes simplex and HPV

Genital herpes begins with tingling or burning, then grouped painful vesicles on an erythematous base that ulcerate and crust. The first episode is the most severe and may bring fever, tender inguinal nodes and sacral radiculitis (buttock and leg pain, urinary retention, constipation) because the virus travels to and becomes latent in the sacral dorsal root ganglia. Recurrences are milder and often preceded by a prodrome of tingling or buttock and thigh pain that can mimic sciatica. Asymptomatic viral shedding explains most transmission. Antivirals (acyclovir, valacyclovir) shorten episodes and suppress recurrences.

Human papillomavirus is the most common sexually transmitted infection. Low risk types 6 and 11 cause condylomata acuminata (soft cauliflower like genital warts); high risk types 16 and 18 cause most cervical cancer and many anal, penile and oropharyngeal cancers (oncoproteins E6 and E7 inactivate p53 and Rb). Prevention relies on vaccination before sexual exposure and cervical screening by Pap cytology and HPV testing; koilocytes are the cytologic hallmark. Do not confuse the flat, moist condylomata lata of secondary syphilis with the warty condylomata acuminata of HPV.

HIV and AIDS

Human immunodeficiency virus is an RNA retrovirus that infects CD4 helper T cells and macrophages and integrates into host DNA. Transmission is sexual, parenteral (shared needles, rarely transfusion) and vertical (pregnancy, birth, breastfeeding). Acute HIV 2 to 4 weeks after exposure resembles mononucleosis (fever, sore throat, lymphadenopathy, rash, myalgia). A long clinical latency follows while CD4 counts fall. AIDS is defined by a CD4 count under 200 cells/µL or an AIDS defining illness. Screening uses a fourth generation antigen and antibody test. With modern antiretroviral therapy, people with HIV who achieve an undetectable viral load have a near normal life expectancy and do not transmit the virus sexually ("undetectable equals untransmittable").

CD4 count (cells/µL)Typical opportunistic problems
Under 500Oral candidiasis (thrush), herpes zoster, tuberculosis, oral hairy leukoplakia (EBV), Kaposi sarcoma
Under 200Pneumocystis jirovecii pneumonia, HIV associated dementia, progressive multifocal leukoencephalopathy (JC virus)
Under 100Cerebral toxoplasmosis (ring enhancing lesions), cryptococcal meningitis, esophageal candidiasis, primary CNS lymphoma (EBV)
Under 50Cytomegalovirus retinitis, disseminated Mycobacterium avium complex

Musculoskeletal and neurologic manifestations relevant to a chiropractor include distal symmetric sensory polyneuropathy (painful feet; from HIV itself or older antiretrovirals), myopathy, reactive and psoriatic arthritis, osteoporosis, avascular necrosis, and spinal infection including tuberculous spondylitis. HIV is not transmitted by touch; universal precautions apply to every patient.

Clinical link. A 24 year old with new heel pain, a swollen knee and gritty red eyes three weeks after a bout of dysuria fits reactive arthritis. Ask about recent urethritis or diarrhea, look at the palms, soles and mouth, and refer for evaluation and partner treatment. Conservative care for enthesitis and mobility can help, but the joint must first be shown to be sterile.
Key point

Sexually transmitted infections reach the chiropractic office as joints, tendons, roots and cords: gonococcal septic arthritis and tenosynovitis, chlamydia triggered reactive arthritis, sacral herpetic radiculitis, tabes dorsalis with Charcot joints, and HIV neuropathy and bone disease. Recognize the pattern, take a confidential history, refer for testing and treatment, and use universal precautions with every patient.

Section 4Toxicology and pharmacology for the chiropractor

Why drug knowledge matters without prescribing

Chiropractors do not prescribe, but drugs change the examination (masked pain, blunted heart rate), the risk of care (bleeding, bone fragility, tendon rupture, falls) and the differential diagnosis, because an adverse drug effect may be the complaint. Update the drug list at every re examination.

Drug classExamplesEffects that matter to chiropractic care
StatinsAtorvastatin, simvastatinMyalgia and, rarely, myopathy or rhabdomyolysis (check CK; dark urine); risk rises with fibrates and some antibiotics
FluoroquinolonesCiprofloxacin, levofloxacinAchilles tendinopathy and rupture, worse with age over 60 and corticosteroids; peripheral neuropathy
Beta blockersMetoprolol, propranololBlunted heart rate response to exercise and hypoglycemia; fatigue; may worsen asthma
Antihypertensives and diureticsACE inhibitors, thiazides, loop diuretics, alpha blockersOrthostatic hypotension on rising from the table; electrolyte disturbance and cramps; ACE inhibitor cough and angioedema; thiazides raise uric acid (gout)
SSRIs and SNRIsSertraline, fluoxetine, venlafaxineIncreased bleeding risk (platelet serotonin depletion), hyponatremia in the elderly, serotonin syndrome with tramadol, triptans or St John's wort

NSAIDs and acetaminophen

Nonsteroidal anti inflammatory drugs inhibit cyclooxygenase (COX), blocking conversion of arachidonic acid to prostaglandins and thromboxane. COX 1 is constitutive (gastric mucosal protection, platelet thromboxane A2, renal blood flow); COX 2 is induced by inflammation. Aspirin acetylates COX irreversibly, so its antiplatelet effect lasts the life of the platelet (7 to 10 days); other NSAIDs (ibuprofen, naproxen) are reversible. Selective COX 2 inhibitors (celecoxib) spare the stomach but raise cardiovascular risk.

Acetaminophen (paracetamol) is analgesic and antipyretic but not anti inflammatory and does not harm the stomach or platelets. Overdose saturates conjugation pathways, so more drug goes to the toxic metabolite NAPQI, which depletes glutathione and causes centrilobular hepatic necrosis 1 to 3 days later; the antidote is N acetylcysteine. Maximum adult dose is generally 4 g per day, lower with alcohol use or liver disease.

Opioids

Opioids act on mu receptors to produce analgesia, euphoria, sedation, respiratory depression, miosis, constipation (to which tolerance does not develop) and nausea. For chronic low back pain, long term use has weak evidence of benefit and clear harms (tolerance, opioid use disorder, hyperalgesia, falls, overdose); guidelines favor nonpharmacologic care, including spinal manipulation and exercise, first. Opioid overdose presents with the triad of coma, pinpoint pupils and respiratory depression; the antidote is naloxone, which is short acting, so the patient must still be transported because sedation can recur.

Corticosteroids

Long term systemic glucocorticoids (prednisone, dexamethasone) bring predictable problems: osteoporosis and vertebral fractures (the most common secondary cause), avascular necrosis of the femoral head, steroid myopathy (proximal weakness), tendon weakening, poor wound healing, infection risk with masked fever, hyperglycemia, hypertension, weight gain with Cushingoid features, cataracts and mood change. Chronic use suppresses the hypothalamic pituitary adrenal axis, so abrupt cessation risks adrenal crisis (hypotension, weakness, vomiting, collapse). A patient taking chronic steroids is a red flag case: consider fracture on new back pain, choose low force technique, and watch for infection.

Anticoagulants and antiplatelet drugs

DrugMechanismMonitoring and reversal
WarfarinVitamin K epoxide reductase inhibitor; lowers factors II, VII, IX, X and proteins C and SPT and INR (target usually 2 to 3); vitamin K and prothrombin complex concentrate; many food and drug interactions
Heparin (unfractionated)Activates antithrombin, inhibiting thrombin and factor XaaPTT; protamine sulfate; heparin induced thrombocytopenia
Low molecular weight heparin (enoxaparin)Mainly anti factor XaUsually no routine monitoring
Direct oral anticoagulantsFactor Xa inhibitors (apixaban, rivaroxaban) or direct thrombin inhibitor (dabigatran)No routine monitoring; specific reversal agents exist
Antiplatelet drugsAspirin (COX); clopidogrel (P2Y12 ADP receptor)Bleeding time effect lasts for platelet life

Anticoagulated patients bruise easily and are at risk of epidural, retroperitoneal and intracranial hemorrhage. Use caution with forceful thrusts and deep soft tissue work, and remember that a sudden severe headache, a new neurologic deficit or acute severe back pain in such a patient may be a bleed. Ginkgo, garlic, high dose fish oil and vitamin E add to bleeding risk; St John's wort and vitamin K rich foods lower warfarin effect.

Board tip. Warfarin is monitored by PT/INR (extrinsic pathway, factor VII has the shortest half life); heparin by aPTT (intrinsic pathway). Aspirin prolongs bleeding time but not PT or aPTT. A stable therapeutic INR is not an absolute contraindication to all manipulation, but a supratherapeutic or unstable INR is, and low force techniques are preferred in all anticoagulated patients.

Poisoning and toxidromes

In any suspected poisoning, ensure scene safety, activate emergency services, support airway, breathing and circulation, and contact a poison control center (in the United States, 1 800 222 1222). Do not induce vomiting. Bring the container to the hospital.

ToxidromeExamplesSignsAntidote or key treatment
AnticholinergicDiphenhydramine, tricyclics, atropine, jimsonweedHot as a hare, dry as a bone, red as a beet, blind as a bat (mydriasis), mad as a hatter; urinary retention, tachycardiaSupportive; physostigmine in selected cases
CholinergicOrganophosphate and carbamate insecticides, nerve agentsDUMBELS: diarrhea, urination, miosis, bradycardia, bronchorrhea, emesis, lacrimation, salivation; muscle fasciculations then weaknessAtropine plus pralidoxime; decontaminate and protect the rescuer
OpioidHeroin, fentanyl, oxycodoneComa, pinpoint pupils, slow shallow breathingNaloxone, ventilation
SympathomimeticCocaine, amphetaminesAgitation, hypertension, tachycardia, hyperthermia, mydriasis, sweatingBenzodiazepines, cooling
Serotonin syndromeSSRIs with tramadol, triptans, MAO inhibitorsAgitation, hyperthermia, diarrhea, clonus and hyperreflexia (lower limbs)Stop drugs, benzodiazepines, cyproheptadine

Environmental and occupational toxins

Membrane phospholipids phospholipase A2 Corticosteroids block here Arachidonic acid COX 1 (constitutive) COX 2 (inducible) Gastric mucosal protection Platelet thromboxane A2 Renal blood flow Inflammation and pain Fever Vascular prostacyclin Aspirin (irreversible), ibuprofen, naproxen block both Celecoxib blocks COX 2 only
Figure 13.5 Corticosteroids act upstream, reducing arachidonic acid release; NSAIDs block cyclooxygenase. Blocking COX 1 explains ulcers, bleeding and renal effects; blocking COX 2 explains anti inflammatory benefit.
Key point

Know what your patients take and what it means: NSAIDs threaten the stomach, kidneys and heart; opioids depress breathing and carry addiction risk; corticosteroids weaken bone and tendon and mask infection; anticoagulants raise bleeding risk and call for lower force; statins and fluoroquinolones injure muscle and tendon. Recognize toxidromes and occupational exposures, call for help early, and communicate with prescribers rather than changing medication yourself.

Section 5Emergency procedures

Scene safety and the primary survey

Every office needs a written emergency plan, BLS certified staff, an automated external defibrillator and glucose. In any emergency, first confirm the scene is safe (electrical hazards, toxic exposure, violence), then check responsiveness, shout for help, call emergency medical services (EMS) and send someone for the AED. The primary survey follows the ABCDE order: airway (with cervical spine protection in trauma), breathing, circulation (pulse, major bleeding, skin signs), disability (level of consciousness by AVPU: alert, responds to voice, responds to pain, unresponsive; pupils) and exposure. Stop major external bleeding with firm direct pressure; use a tourniquet above the wound for life threatening limb bleeding that pressure does not control.

CPR and AED

Adult cardiac arrest is most often due to ventricular fibrillation or pulseless ventricular tachycardia, which are shockable rhythms; survival falls by roughly 7 to 10 percent for each minute without CPR and defibrillation.

ElementAdultChild (1 year to puberty)Infant (under 1 year)
Pulse check (10 seconds max)CarotidCarotid or femoralBrachial
Compression depthAt least 2 inches (5 cm), not over 2.4 inches (6 cm)About 2 inches (5 cm), one third of chest depthAbout 1.5 inches (4 cm), one third of chest depth
Hand positionHeel of both hands, lower half of sternumOne or two hands, lower half of sternumTwo fingers or two thumb encircling, just below the nipple line
Rate100 to 120 per minute, full recoil, interruptions under 10 seconds
Ratio, single rescuer30:230:230:2
Ratio, two rescuers30:215:215:2

Begin compressions immediately for an unresponsive person who is not breathing or only gasping (agonal breathing is a sign of arrest). The sequence is C A B: compressions, airway (head tilt chin lift, or jaw thrust if spinal injury is suspected), breathing (each breath over 1 second with visible chest rise). Attach the AED as soon as it arrives, follow its prompts, make sure no one touches the patient during analysis and shock, and resume compressions immediately after the shock. Pads go below the right clavicle and on the left lateral chest; dry the chest and remove medication patches. Use pediatric pads for children under 8 if available.

Scene safe? Tap and shout Unresponsive: shout for help Call EMS, send for the AED Breathing and pulse check, 10 seconds at most No pulse, not breathing or gasping: CPR 30:2 AED arrives: pads on, analyze Shock advised: shock, CPR 2 min No shock: CPR 2 min, reanalyze Pulse but not breathing:1 breath every 6 s
Figure 13.6 Adult basic life support. The priorities are early recognition, an immediate call for EMS and the AED, high quality compressions with minimal interruption, and defibrillation as soon as the AED advises a shock.

Choking

Severe obstruction (cannot speak, cough or breathe; the universal choking sign of hands at the throat; cyanosis): for a responsive adult or child give abdominal thrusts (Heimlich maneuver) just above the umbilicus until the object is expelled or the patient becomes unresponsive; use chest thrusts in pregnancy or obesity. For an infant give cycles of 5 back blows and 5 chest thrusts with the head lower than the chest; never abdominal thrusts. If the patient becomes unresponsive, lower them to the floor, call EMS and start CPR, looking in the mouth for the object before each set of breaths and removing it only if seen (no blind finger sweeps).

Shock

Shock is inadequate tissue perfusion. Early signs are anxiety, tachycardia, tachypnea, cool clammy pale skin and delayed capillary refill; hypotension is a late sign, especially in young adults and children.

TypeCauseDistinguishing feature
HypovolemicHemorrhage, dehydration, burnsCold clammy skin, flat neck veins
CardiogenicMyocardial infarction, arrhythmiaCold skin, distended neck veins, pulmonary edema
ObstructiveTension pneumothorax, tamponade, pulmonary embolismDistended neck veins, sudden dyspnea
Distributive: septic and anaphylacticInfection, allergenWarm flushed skin early; urticaria, wheeze and swelling in anaphylaxis
Distributive: neurogenicCervical or high thoracic cord injury (above T6)Hypotension with bradycardia and warm dry skin (lost sympathetic tone)

First aid: call EMS, lay the patient supine, control bleeding, keep warm, give nothing by mouth, and monitor airway and breathing.

Head and spinal injury

After trauma, any patient with altered consciousness, neck pain, midline tenderness, a neurologic deficit, a dangerous mechanism, intoxication or a distracting injury should be presumed to have a spinal injury: keep the head and neck still in neutral (manual in line stabilization), do not move the patient unless the scene is unsafe, and use a jaw thrust rather than head tilt to open the airway. The Canadian C spine rule and NEXUS criteria identify alert, stable patients who need imaging. A suspected concussion (headache, confusion, amnesia, dizziness, often without loss of consciousness) means removal from play that day and a graded return. Refer emergently for:

Thermal injuries

Burns are classified by depth: superficial (first degree; epidermis; red, painful, no blisters, like sunburn), partial thickness (second degree; into dermis; blisters, very painful), and full thickness (third degree; through dermis; white, leathery or charred, painless because nerve endings are destroyed). The rule of nines estimates adult body surface area burned: head 9 percent, each arm 9, front of trunk 18, back of trunk 18, each leg 18, perineum 1; the patient's palm is about 1 percent. Cool a burn with cool running water for about 20 minutes, remove jewelry, cover loosely with a clean dressing, and never apply ice, butter or ointment. Refer full thickness, large, circumferential, electrical, chemical and inhalation burns and burns of the face, hands, feet, genitals or joints.

Heat illnessCore temperature and mental statusSignsAction
Heat exhaustionUp to about 104°F (40°C), mental status normalHeavy sweating, weakness, headache, nausea, tachycardia, faintingCool environment, fluids, elevate legs, monitor
Heat strokeAbove 104°F (40°C) with CNS dysfunctionConfusion, seizures, collapse; skin may be dry or still sweating (exertional)Emergency: call EMS and cool immediately, ideally by cold water immersion

Hypothermia (core below 95°F or 35°C) progresses from shivering and confusion to loss of shivering, bradycardia and arrhythmias; handle gently, remove wet clothing and rewarm. Rewarm frostbite in warm water only if refreezing will not occur, and never rub it.

Fractures, dislocations, sprains and strains

Signs of fracture include deformity, point bony tenderness, swelling, crepitus, loss of function and inability to bear weight. The Ottawa ankle rules call for radiographs when there is bone tenderness at the posterior edge or tip of either malleolus, at the base of the fifth metatarsal or the navicular, or inability to bear weight for four steps both immediately and in the office. Splint fractures in the position found, including the joint above and below, and check distal pulse, sensation and capillary refill before and after splinting. Open fractures need a sterile dressing and emergency transfer. Watch for compartment syndrome after tibial or forearm fractures and crush injuries: pain out of proportion and on passive stretch is the earliest sign, followed by paresthesia, pallor, pulselessness and paralysis; it is a surgical emergency.

Dislocations should generally be splinted and referred; do not attempt reduction of a first time dislocation where fracture or neurovascular injury has not been excluded. The shoulder dislocates anteriorly in about 95 percent of cases (axillary nerve at risk: numb "regimental badge" area over the deltoid); posterior shoulder dislocation follows seizures and electrocution. Posterior hip dislocation (dashboard injury) holds the limb flexed, adducted and internally rotated. Sprains (ligament) and strains (muscle or tendon) are graded I (microscopic tearing, stable), II (partial tear, some laxity) and III (complete rupture, gross laxity or a palpable defect). Acute care is protection, relative rest with early optimal loading, compression and elevation, then progressive rehabilitation.

Syncope, diabetic and allergic emergencies

Syncope is transient loss of consciousness from global cerebral hypoperfusion with spontaneous full recovery. The most common type is vasovagal (triggered by pain, fear or prolonged standing, with a prodrome of nausea, warmth and pallor). Orthostatic syncope follows standing up, especially in older adults on antihypertensives. Cardiac syncope (sudden, without warning, during exertion, while supine, with palpitations, or with a family history of sudden death) suggests arrhythmia or aortic stenosis and is dangerous. Lay the patient supine with legs raised and check breathing and pulse; call EMS for exertional or unexplained syncope, injury, chest pain or persistent confusion.

FeatureHypoglycemiaHyperglycemic crisis (DKA or HHS)
OnsetMinutes (missed meal, extra insulin or exercise)Hours to days
SignsSweating, tremor, palpitations, hunger, confusion, irritability, seizure, comaPolyuria, thirst, dehydration, warm dry skin; DKA: fruity breath, Kussmaul breathing, abdominal pain
Blood glucoseUnder 70 mg/dLOver 250 mg/dL (DKA) or often over 600 (HHS)
Office actionIf awake and able to swallow: 15 to 20 g fast sugar (juice, glucose tablets), recheck in 15 minutes ("rule of 15"), then a snack; if unconscious: nothing by mouth, call EMS, glucagon if availableCall EMS; fluids and insulin in hospital

Anaphylaxis is a severe, rapid, systemic IgE mediated (or other mast cell) reaction: urticaria, flushing, lip and tongue swelling, wheeze, stridor, hypotension, abdominal cramps and a sense of doom, within minutes of exposure (insect sting, food, latex, drug). Call EMS, give intramuscular epinephrine into the anterolateral thigh with the patient's auto injector (0.3 mg adult, 0.15 mg small child), position supine with legs raised (or sitting if breathing is difficult), and repeat in 5 to 15 minutes if needed. Antihistamines do not treat airway or circulatory compromise. A biphasic reaction can recur hours later, so every patient needs emergency department evaluation.

Board tip. When in doubt in a diabetic patient who is confused, give sugar if they can swallow safely: it rapidly reverses hypoglycemia and does little harm in hyperglycemia. Epinephrine is the first and most important drug in anaphylaxis, given intramuscularly in the lateral thigh; delay in epinephrine is the main factor in fatal reactions.
Clinical link. A patient who feels lightheaded, pale and sweaty right after a cervical adjustment is most often having a vasovagal reaction, but sudden severe headache, vertigo with nystagmus, diplopia, dysarthria, dysphagia, drop attack, ataxia or numbness suggests vertebrobasilar ischemia or cervical artery dissection. Stop treatment, keep the patient still and supine, perform a brief neurologic check, and call EMS. Document the time and findings.
Key point

Office emergencies are handled by preparation and sequence: scene safety, call for help and the AED, then airway, breathing and circulation. Deliver high quality CPR and defibrillate early, clear obstructed airways with thrusts, recognize shock types, protect the spine after trauma, cool burns and heat stroke, splint and refer fractures, and treat hypoglycemia with sugar and anaphylaxis with intramuscular epinephrine.

The chapter in one breath

  • Aging reduces physiologic reserve, so older adults present atypically; a sudden change in function is a symptom.
  • Screen for falls with three questions and the Timed Up and Go (12 seconds or more is abnormal); psychoactive drugs and orthostasis are key modifiable causes.
  • Osteoporosis is a T score of −2.5 or lower or a fragility fracture; labs are normal; glucocorticoids are the leading drug cause.
  • Delirium is acute, fluctuating and inattentive and needs same day referral; dementia is chronic and progressive.
  • Name skin lesions precisely; use the ABCDE rule and the ugly duckling sign to refer pigmented lesions; Breslow depth drives melanoma prognosis.
  • Disseminated gonococcal infection causes tenosynovitis, pustules and septic arthritis; reactive arthritis follows chlamydia or enteric infection and is HLA B27 linked.
  • Late syphilis causes tabes dorsalis (dorsal columns, positive Romberg, Argyll Robertson pupils) and Charcot joints.
  • NSAIDs threaten gut, kidney and heart; corticosteroids weaken bone and tendon; anticoagulants call for low force care; fluoroquinolones rupture Achilles tendons.
  • In arrest: call EMS, get the AED, push hard and fast (100 to 120 per minute, at least 2 inches) at 30:2, and shock early.
  • Give sugar for hypoglycemia if the patient can swallow, and intramuscular epinephrine first for anaphylaxis.

Words worth knowing

TermWhat it means
HomeostenosisAge related narrowing of physiologic reserve, so stress causes earlier decompensation.
SarcopeniaAge related loss of muscle mass, strength and power.
T scoreBone density compared with a young adult mean, in standard deviations.
PolypharmacyUse of five or more medications at once.
Prescribing cascadeTreating a drug side effect as a new disease with another drug.
Beers CriteriaA list of potentially inappropriate medications for older adults.
DeliriumAcute, fluctuating disturbance of attention and awareness from a medical cause.
MaculeA flat, nonpalpable color change under 1 cm.
Koebner phenomenonNew lesions of a skin disease appearing at sites of trauma, as in psoriasis.
Nikolsky signShearing of the epidermis with lateral finger pressure, positive in pemphigus vulgaris.
Actinic keratosisA rough, scaly, sun induced premalignant lesion that can become squamous cell carcinoma.
Breslow thicknessDepth of melanoma invasion in millimeters, the main prognostic factor.
ChancreThe painless indurated ulcer of primary syphilis.
Tabes dorsalisLate neurosyphilis with degeneration of the dorsal columns and dorsal roots.
Argyll Robertson pupilA small pupil that constricts to accommodation but not to light.
Charcot jointA joint destroyed by repeated trauma after loss of pain and position sense.
Reactive arthritisSterile HLA B27 associated arthritis after a genitourinary or enteric infection.
NAPQIThe toxic acetaminophen metabolite that causes liver necrosis in overdose.
ToxidromeA recognizable cluster of signs produced by a class of poison.
Neurogenic shockHypotension with bradycardia from loss of sympathetic tone after high cord injury.
Rule of ninesMethod that assigns body regions multiples of 9 percent to estimate burn area.
Compartment syndromeRaised pressure in a closed muscle compartment that threatens perfusion; pain on passive stretch is an early sign.
AnaphylaxisA rapid, severe systemic allergic reaction treated first with intramuscular epinephrine.

Check yourself

An 82 year old on a benzodiazepine for sleep takes 15 seconds on the Timed Up and Go. What does this mean and what is the most modifiable factor?
High fall risk; the sedative. A TUG of 12 seconds or more indicates increased fall risk, and psychoactive drugs are among the most modifiable causes.
A 68 year old woman has a T score of −2.7 with normal calcium, phosphate and alkaline phosphatase. Diagnosis?
Osteoporosis. A T score of −2.5 or lower defines it, and labs are normal.
An elderly patient who was normal last week is now drowsy, inattentive and confused, worse at night. What is it and what do you do?
Delirium; same day medical referral. Acute onset, fluctuation and inattention define delirium, a sign of underlying medical illness.
During a visit you see a 9 mm asymmetric mole with black, brown and red areas that the patient says has grown. What should you do?
Refer promptly to a dermatologist for biopsy. It meets several ABCDE criteria, including evolution, the most sensitive feature for melanoma.
An elderly patient has tense bullae on the flexures, no oral lesions and a negative Nikolsky sign. Likely diagnosis?
Bullous pemphigoid. Subepidermal antibodies against hemidesmosomes produce tense blisters; pemphigus vulgaris is flaccid with a positive Nikolsky sign.
A 22 year old has wrist tenosynovitis, migratory joint pain and a few pustules on the hands. What organism is most likely?
Neisseria gonorrhoeae. This is the arthritis dermatitis form of disseminated gonococcal infection; refer for mucosal testing and ceftriaxone.
A patient has a stamping gait, positive Romberg, absent ankle reflexes, lancinating leg pains and pupils that accommodate but do not react to light. Which structures are damaged?
Dorsal columns and dorsal roots (tabes dorsalis). Late neurosyphilis; the Argyll Robertson pupil is the clue.
A 70 year old taking ciprofloxacin and prednisone develops sudden posterior heel pain while climbing stairs. What injury do you suspect?
Achilles tendon rupture. Fluoroquinolones raise rupture risk, most in patients over 60 and those taking corticosteroids.
A farm worker has diarrhea, drooling, tearing, pinpoint pupils, bradycardia and wheezing. What is the poisoning and its antidotes?
Organophosphate (cholinergic) poisoning: atropine and pralidoxime. Acetylcholinesterase inhibition causes the DUMBELS picture.
A diabetic patient becomes sweaty, shaky and confused in the waiting room but can still swallow. What is the first step?
Give 15 to 20 g of fast acting sugar and recheck in 15 minutes. Hypoglycemia is the likely cause; if unable to swallow, nothing by mouth and call EMS.