← Chapter 14
Microbiology · Chapter 14

Grafts and Rejection

A transplant hands the immune system a puzzle. Are these cells self or not? The answer comes from the MHC and HLA markers the graft carries. Choose where the tissue comes from, set how well it matches and how hard you suppress, then run the clock from the first minutes out to ten years.

Donor, recipient, and the graft6 of 6 matched

Donor and recipient markers, and the graft
Green chips match. Red chips are foreign, and foreign chips are what gets attacked.

Graft function over ten yearseach step on the axis is ten times longer

Graft function from minutes out to ten years
30 min
Set up a transplantpick the donor, then run the clock
Where the tissue comes from
4 of 6
6
Has this person met foreign tissue before?
Graft working
100%
Infection risk
normal
Match the word to the donor. Auto means self. Iso means an identical twin. Allo means another person. Xeno means another species. The further from self, the harder the attack.