When tissue is hurt or invaded, the innate system answers within minutes. It shows itself through four classic signs: redness, heat, swelling, and pain. Step through the response to see what each sign is really telling you. Then dial the mediators up and let the same response run body-wide.
A patch of injured tissuestep 1 of 6
Dial the mediatorslive model
55
Blood flow
100%
Tissue fluid
0 mL
Blood pressure
120
The inflammatory responsepress Next to begin
The classic four are rubor, calor, tumor, dolor. A fifth, functio laesa, meaning loss of function, is often counted too.